A few studies have reported the association between asthma and osteoporosis. We aimed to analyze the association of asthma and its subgroups with osteoporosis in the Korean adult population. We used the health examinee (HEXA) data from the Korean Genome and Epidemiology Study (KoGES) obtained between 2004 and 2016. We included 162,579 participants (n = 3,160 with asthma; n = 159,419 controls) who reported their previous histories of asthma and osteoporosis. The participants were categorized into 3 groups based on asthma management: participants who did not need further treatment due to controlled symptoms (well controlled); participants with ongoing treatment (being treated); participants who were not treated even though they had symptoms (not being treated). Multiple logistic regression analyses were used to calculate the adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for osteoporosis. Subgroup analyses for age and sex were conducted. The prevalence of osteoporosis was higher in patients with asthma (13.6%) than in controls (6.8%). In the full-adjusted model, the aORs for osteoporosis were 1.74 (95% CI 1.55–1.94, P < 0.001) in patients with asthma compared to controls. There were consistent findings across the age and sex subgroups. The aORs for osteoporosis were 1.43 (95% CI 1.10–1.86, P = 0.008) in the well-controlled asthma group; 1.55 (95% CI 1.28–1.89, P < 0.001) in the being treated asthma group; and 1.96 (95% CI 1.66–2.31, P < 0.001) in the not being treated asthma group compared to the control group. Asthma was associated with osteoporosis in the Korean adult population. Patients with asthma not being treated showed the highest ORs for osteoporosis.

中文翻译：

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哮喘及其亚组与骨质疏松症的关联：使用 KoGES HEXA 数据的横断面研究

一些研究报告了哮喘和骨质疏松症之间的关联。我们旨在分析哮喘及其亚组与韩国成年人群骨质疏松症的关系。我们使用了 2004 年至 2016 年间获得的韩国基因组和流行病学研究 (KoGES) 的健康检查者 (HEXA) 数据。我们纳入了 162,579 名参与者（n = 3,160 患有哮喘；n = 159,419 名对照组），他们报告了他们以前的哮喘和骨质疏松症病史. 根据哮喘管理将参与者分为 3 组：由于症状得到控制而无需进一步治疗的参与者（控制良好）；正在接受治疗（正在接受治疗）的参与者；即使有症状（未接受治疗）也未接受治疗的参与者。多元逻辑回归分析用于计算骨质疏松症的调整优势比 (aOR) 和 95% 置信区间 (CI)。进行了年龄和性别的亚组分析。哮喘患者的骨质疏松症患病率（13.6%）高于对照组（6.8%）。在完全调整的模型中，与对照组相比，哮喘患者骨质疏松的 aOR 为 1.74（95% CI 1.55-1.94，P < 0.001）。在年龄和性别亚组中都有一致的发现。在控制良好的哮喘组中，骨质疏松症的 aOR 为 1.43（95% CI 1.10-1.86，P = 0.008）；正在治疗的哮喘组中为 1.55 (95% CI 1.28–1.89, P < 0.001)；与对照组相比，未治疗哮喘组的 1.96 (95% CI 1.66–2.31, P < 0.001)。在韩国成年人群中，哮喘与骨质疏松症有关。未接受治疗的哮喘患者表现出最高的骨质疏松症 OR。