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Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis
Journal of Inflammation Research ( IF 4.2 ) Pub Date : 2020-09-25 , DOI: 10.2147/jir.s265811 Safaa A A Khaled 1 , Eman NasrEldin 2 , Yasmine S Makarem 3 , Hamdy F F Mahmoud 4, 5
Journal of Inflammation Research ( IF 4.2 ) Pub Date : 2020-09-25 , DOI: 10.2147/jir.s265811 Safaa A A Khaled 1 , Eman NasrEldin 2 , Yasmine S Makarem 3 , Hamdy F F Mahmoud 4, 5
Affiliation
Background and Objective: Disease activity score 28 (DAS28) for rheumatoid arthritis (RA) is the commonly used DAS; it relies on clinical parameters that could be subjective. This work aimed to create a more accurate DAS for RA and assess its validity.
Patients and Methods: The study included 98 RA patients and 53 matched controls; they were interviewed, clinically examined, their visual analogue scales (VAS) were reported, and then blood samples were withdrawn for erythrocyte sedimentation rate (ESR), complete blood count (CBC), and C-reactive protein (CRP). Platelet indices (PIs) were obtained from the CBC including Plt (platelet count), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). DAS28 was calculated for each patient using RheumaHelper mobile software. Minitab Statistical Package® and SPSS v20 software were used for data analysis.
Results and Conclusions: Results revealed perfect matching between patients and controls as regarding age and gender. ESR, CRP and PDW were significantly higher in patients than controls; also positive correlations were detected among these variables. A new DAS for RA was developed; ESR, CRP, PDW and MPV were the components for this index. Further analyses showed that this new score was significantly higher in patients than controls and correlated with DAS28 of the patients. Furthermore the new score could identify RA patients from healthy subjects (cut off value < − 0.79) and stratified RA patients according to their disease activity into low, intermediate, high, or in remission. Conclusively, we developed a more precise, easily obtained new DAS for RA. This new DAS has both diagnostic/prognostic values in patients with RA.
Keywords: rheumatoid arthritis, platelet indices, disease activity
中文翻译：
血小板分布宽度和平均血小板体积在类风湿关节炎疾病活动评分中的价值
背景与目的：类风湿关节炎（RA）的疾病活动评分28（DAS28）是常用的DAS；它依赖于可能是主观的临床参数。这项工作旨在为 RA 创建更准确的 DAS 并评估其有效性。
患者和方法：该研究包括 98 名 RA 患者和 53 名匹配的对照；他们接受了采访，临床检查，报告了他们的视觉模拟评分（VAS），然后抽取血样进行红细胞沉降率（ESR）、全血细胞计数（CBC）和C反应蛋白（CRP）。血小板指数 (PI) 从 CBC 获得，包括 Plt (血小板计数)、平均血小板体积 (MPV)、血小板分布宽度 (PDW) 和血小板比容 (PCT)。使用 RheumaHelper 移动软件计算每位患者的 DAS28。Minitab Statistical Package ®和 SPSS v20 软件用于数据分析。
结果和结论：结果显示，患者和对照组在年龄和性别方面完美匹配。患者的 ESR、CRP 和 PDW 显着高于对照组；在这些变量之间也检测到正相关。为 RA 开发了一种新的 DAS；ESR、CRP、PDW 和 MPV 是该指数的组成部分。进一步的分析表明，患者的这一新分数明显高于对照组，并且与患者的 DAS28 相关。此外，新评分可以从健康受试者中识别出 RA 患者（临界值 < - 0.79），并根据 RA 患者的疾病活动度将其分为低、中、高或缓解。最后，我们为 RA 开发了一种更精确、更容易获得的新 DAS。这种新的 DAS 对 RA 患者具有诊断/预后价值。
关键词：类风湿性关节炎，血小板指数，疾病活动度
更新日期：2020-09-25
Patients and Methods: The study included 98 RA patients and 53 matched controls; they were interviewed, clinically examined, their visual analogue scales (VAS) were reported, and then blood samples were withdrawn for erythrocyte sedimentation rate (ESR), complete blood count (CBC), and C-reactive protein (CRP). Platelet indices (PIs) were obtained from the CBC including Plt (platelet count), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). DAS28 was calculated for each patient using RheumaHelper mobile software. Minitab Statistical Package® and SPSS v20 software were used for data analysis.
Results and Conclusions: Results revealed perfect matching between patients and controls as regarding age and gender. ESR, CRP and PDW were significantly higher in patients than controls; also positive correlations were detected among these variables. A new DAS for RA was developed; ESR, CRP, PDW and MPV were the components for this index. Further analyses showed that this new score was significantly higher in patients than controls and correlated with DAS28 of the patients. Furthermore the new score could identify RA patients from healthy subjects (cut off value < − 0.79) and stratified RA patients according to their disease activity into low, intermediate, high, or in remission. Conclusively, we developed a more precise, easily obtained new DAS for RA. This new DAS has both diagnostic/prognostic values in patients with RA.
Keywords: rheumatoid arthritis, platelet indices, disease activity
中文翻译：
血小板分布宽度和平均血小板体积在类风湿关节炎疾病活动评分中的价值
背景与目的：类风湿关节炎（RA）的疾病活动评分28（DAS28）是常用的DAS；它依赖于可能是主观的临床参数。这项工作旨在为 RA 创建更准确的 DAS 并评估其有效性。
患者和方法：该研究包括 98 名 RA 患者和 53 名匹配的对照；他们接受了采访，临床检查，报告了他们的视觉模拟评分（VAS），然后抽取血样进行红细胞沉降率（ESR）、全血细胞计数（CBC）和C反应蛋白（CRP）。血小板指数 (PI) 从 CBC 获得，包括 Plt (血小板计数)、平均血小板体积 (MPV)、血小板分布宽度 (PDW) 和血小板比容 (PCT)。使用 RheumaHelper 移动软件计算每位患者的 DAS28。Minitab Statistical Package ®和 SPSS v20 软件用于数据分析。
结果和结论：结果显示，患者和对照组在年龄和性别方面完美匹配。患者的 ESR、CRP 和 PDW 显着高于对照组；在这些变量之间也检测到正相关。为 RA 开发了一种新的 DAS；ESR、CRP、PDW 和 MPV 是该指数的组成部分。进一步的分析表明，患者的这一新分数明显高于对照组，并且与患者的 DAS28 相关。此外，新评分可以从健康受试者中识别出 RA 患者（临界值 < - 0.79），并根据 RA 患者的疾病活动度将其分为低、中、高或缓解。最后，我们为 RA 开发了一种更精确、更容易获得的新 DAS。这种新的 DAS 对 RA 患者具有诊断/预后价值。
关键词：类风湿性关节炎，血小板指数，疾病活动度
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