Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Strain Among Men Who Have Sex with Men in Liaoning, China,AIDS Research and Human Retroviruses

当前位置： X-MOL 学术 › AIDS Res. Hum. Retrovir. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Strain Among Men Who Have Sex with Men in Liaoning, China
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2020-12-31 , DOI: 10.1089/aid.2020.0223
Shan He _{1,

2,

3} , Yang Gao _{1,

2,

3} , Minghui An _{1,

2,

3} , Bin Zhao _{1,

2,

3} , Lin Wang _{1,

2,

3} , Haibo Ding _{1,

2,

3} , Xiaoxu Han _{1,

2,

3}

Affiliation

CRF01_AE and CRF07_BC are two widespread human immunodeficiency virus type 1 (HIV-1) strains among different high-risk populations, including men who have sex with men (MSM), in China. This co-epidemic of various HIV strains enables the production of second-generation recombinants. In this study, we detected a novel HIV-1 CRF01_AE/CRF07_BC recombinant from LN321945, an MSM lived in Liaoning province, northeast China. The phylogenetic and recombination analyses indicated the near full-length genome (NFLG) sequence of LN321945 had six recombination breakpoints, with three CRF07_BC fragments inserted into a CRF01_AE backbone. Further subregion trees analysis revealed that both CRF01_AE and CRF07_BC fragments were derived from two predominant HIV-1 strains among MSM. In addition, the NFLG of LN321945 was revealed to be clustered closely to another CRF01_AE/CRF07_BC recombinant previously identified in Shaanxi province, northwest China, but these two recombinants had distinct recombination structure and origin of CRF01_AE fragments. Hence, this study identified a second-generation recombinant between the main strains circulating among MSM, indicating more complicated trend of HIV-1 epidemic in China.

更新日期：2021-01-07

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11