Dementias with predominant language involvement, called primary progressive aphasias provide us with unique insight into systematic breakdown of language in neurodegenerative diseases and the structures and networks involved. Clinical and neuroimaging models quite distinct from those seen in stroke aphasias have evolved. In this short overview, we will discuss the cognitive processes involved in expressive and receptive verbal communication and how these processes are affected in the different variants of primary progressive aphasia producing distinctive clinical patterns. We will also discuss the brain's language network and how different components of the network break down in each of the primary progressive aphasia variants.


中文翻译：

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原发性进行性失语症的语言分解


具有主要语言参与的痴呆症，称为原发性进行性失语症，为我们提供了对神经退行性疾病中语言的系统分解以及所涉及的结构和网络的独特见解。与卒中失语症所见的临床和神经影像学模型已经完全不同。在这个简短的概述中，我们将讨论表达性和接受性言语交流所涉及的认知过程，以及这些过程如何在原发性失语症的不同变异中产生不同的临床模式而受到影响。我们还将讨论大脑的语言网络以及在每个主要进行性失语症变体中网络的不同组成部分如何分解。