Introduction: Contemporary neuro-imaging techniques have significantly advanced our understanding of the brain organization of language and the involvement of subcortical areas in aphasia. However, articles on sub-cortical aphasia, particularly in non-western languages, remain to be few and far between. We set out to explore aphasia typology in sub-cortical strokes among Bengali-speaking population with a focus towards providing a longitudinal view over a period of 3 months post-stroke. Methods: Bengali version of Western Aphasia Battery (BWAB) was used to assess and classify language dysfunction in our study participants. Conventional brain imaging techniques (CT scan & MRI) were used to detect and localize strokes. Uni-variate analysis for categorical variable (location versus aphasia typology) was performed using Chi square and Fischer's exact test (as applicable). Directional measures were calculated using lambda and Goodman-Kruskal tau (Range of -1 to + 1). Boot strapping was applied while calculating the directional measures because of inadequate numbers in some sub-sections the sample. Results: Frequency of sub-cortical aphasia was observed to be 29.80% (62/208) in the index study. Four location of strokes were associated with language dysfunction, of which putamen (53.23%) was the commonest followed by striato-capsular region (33.87%). Thalamus and peri-ventricular white matter (PVWM) strokes (6.45% each) were infrequent in our sample of sub-cortical aphasia. Global aphasia (30/62, 48.38%) was the most frequent type observed in acute phase while Broca's aphasia (23/53, 43.39%) dominated among the follow up cases. Aphasia recovery (with follow up AQ of 90.0 or more) was observed in 12 (22.64%) patients of whom majority (8/12) had striato-capsular strokes. Conclusion: The present paper illustrates the epidemiological aspects as well as longitudinal course aphasia following pure sub-cortical strokes.


中文翻译：

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单纯皮质下中风所致失语症的纵向研究



简介：当代神经影像技术极大地增进了我们对语言的大脑组织以及失语症中皮层下区域的参与的理解。然而，关于皮质下失语症的文章，特别是非西方语言的文章，仍然很少。我们着手探索孟加拉语人群中皮质下中风的失语症类型，重点是提供中风后 3 个月内的纵向视图。方法：使用孟加拉语版本的西方失语症测试 (BWAB) 对研究参与者的语言功能障碍进行评估和分类。传统的脑成像技术（CT 扫描和 MRI）用于检测和定位中风。使用卡方和 Fischer 精确检验（如适用）进行分类变量（位置与失语类型）的单变量分析。使用 lambda 和 Goodman-Kruskal tau（范围为 -1 到 + 1）计算方向测量。由于样本中某些子部分的数量不足，在计算方向测量时应用了引导。结果：在指标研究中观察到皮质下失语的频率为 29.80% (62/208)。四个部位的卒中与语言功能障碍相关，其中壳核（53.23%）最常见，其次是纹状体囊区（33.87%）。在我们的皮质下失语症样本中，丘脑和脑室周围白质 (PVWM) 卒中（各 6.45%）并不常见。急性期最常见的是全面性失语（30/62，48.38%），而随访病例中以布罗卡失语（23/53，43.39%）为主。 12 例 (22.0) 中观察到失语症恢复（随访 AQ 为 90.0 或更高）。64%）的患者，其中大多数（8/12）患有纹状体包膜中风。结论：本文阐述了单纯皮质下中风后的流行病学方面以及纵向失语症。