Recent advances in high-throughput long-read sequencers, such as PacBio and Oxford Nanopore sequencers, produce longer reads with more errors than short-read sequencers. In addition to the high error rates of reads, non-uniformity of errors leads to difficulties in various downstream analyses using long reads. Many useful simulators, which characterize long read error patterns and simulate them, have been developed. However, there is still room for improvement in the simulation of the non-uniformity of errors.

中文翻译：

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PBSIM2：长读长测序仪的模拟器，具有新颖的质量分数生成模型。

高通量长读长测序仪（例如 PacBio 和 Oxford Nanopore 测序仪）的最新进展与短读长测序仪相比产生更长的读数，但错误更多。除了读取的高错误率外，错误的不均匀性导致使用长读取的各种下游分析困难重重。已经开发出许多有用的模拟器，这些模拟器可以表征长读取错误模式并对其进行模拟。但在误差不均匀性的模拟方面仍有改进空间。