DNA packs into highly condensed chromatin to organize the genome in eukaryotes but occludes many regulatory DNA elements. Access to DNA within nucleosomes is therefore required for a variety of biological processes in cells including transcription, replication, and DNA repair. To cope with this problem, cells employ a set of specialized ATP-dependent chromatin-remodeling protein complexes to enable dynamic access to packaged DNA. In the present review, we summarize the recent advances in the functional and mechanistic studies on a particular chromatin remodeler SMARCAD1^Fun30 which has been demonstrated to play a key role in distinct cellular processes and gained much attention in recent years. Focus is given to how SMARCAD1^Fun30 regulates various cellular processes through its chromatin remodeling activity, and especially the regulatory role of SMARCAD1^Fun30 in gene expression control, maintenance and establishment of heterochromatin, and DNA damage repair. Moreover, we review the studies on the molecular mechanism of SMARCAD1^Fun30 that promotes the DNA end-resection on double-strand break ends, including the mechanisms of recruitment, activity regulation and chromatin remodeling.

DNA挤入高度浓缩的染色质中，以组织真核生物中的基因组，但封闭了许多调控性DNA元素。因此，细胞中多种生物过程（包括转录，复制和DNA修复）都需要接近核小体中的DNA。为了解决这个问题，细胞采用了一套专门的ATP依赖的染色质重塑蛋白复合物来动态访问包装的DNA。在本综述中，我们总结了对特定染色质重塑剂SMARCAD1 ^Fun30的功能和机理研究的最新进展，该研究已证明其在不同的细胞过程中起着关键作用，近年来受到了广泛关注。重点介绍了SMARCAD1 ^Fun30通过染色质重塑活性来调节各种细胞过程，尤其是SMARCAD1 ^Fun30在基因表达控制，异染色质的维持和建立以及DNA损伤修复中的调节作用。此外，我们审查了有关SMARCAD1 ^Fun30促进双链断裂末端DNA末端切除的分子机制的研究，包括募集，活性调节和染色质重塑的机制。