Tiny changes in the mass of the sensor in a quartz crystal microbalance with dissipation monitoring (QCM-D) can be observed. However, the lack of specificity for target species has hindered the use of QCM-D. Here, molecularly imprinted polymers (MIPs) were used to modify a QCM-D sensor to provide specificity. The MIPs were formed in the presence of sodium dodecyl benzene sulfonate. Imprinted layers on Fe₃O₄ nanoparticles were formed using pyrrole as the functional monomer and cross-linker and methylene blue (MB) as a template. The MIPs produced were then attached to the surface of a QCM-D sensor. The MIPs-coated QCM-D sensor could recognize MB and gave a linear response in the concentration range 25 to 1.5 × 10² µg/L and a detection limit of 1.4 µg/L. The QCM-D sensor was selective for MB over structural analogs. The MIPs-coated QCM-D sensor was successfully used to detect MB in river water and seawater samples, and the recoveries were good. This is the first time MB has been detected using a QCM-D sensor. Mass is an intrinsic property of matter, so this method could easily be extended to other target species by using different MIPs.

中文翻译：

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基于磁印迹聚合物的石英晶体微天平传感器，用于地下水中亚甲基蓝的灵敏无标记检测


可以观察具有耗散监测功能的石英晶体微天平 (QCM-D) 中传感器质量的微小变化。然而，目标物种缺乏特异性阻碍了 QCM-D 的使用。在这里，分子印迹聚合物 (MIP) 用于修改 QCM-D 传感器以提供特异性。 MIP 是在十二烷基苯磺酸钠存在下形成的。以吡咯为功能单体和交联剂，以亚甲基蓝（MB）为模板，在Fe ₃ O ₄纳米粒子上形成印迹层。然后将产生的 MIP 附着到 QCM-D 传感器的表面。 MIPs涂层的QCM-D传感器可以识别MB，并在25至1.5×10 ² µg/L的浓度范围内给出线性响应，检测限为1.4 µg/L。 QCM-D 传感器对 MB 的选择性高于结构类似物。 MIPs涂层的QCM-D传感器成功用于检测河水和海水样品中的MB，回收率良好。这是首次使用 QCM-D 传感器检测到 MB。质量是物质的固有属性，因此通过使用不同的 MIP，该方法可以轻松扩展到其他目标物种。