Abstract

Background

The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL).

Methods

A total of 255 subjects (125 controls and 130 patients) were included. The FABP2 and CRP polymorphisms were determined by PCR-RFLP and AS-PCR methods, respectively. Sd-LDL was measured based on Hirano et al method.

Results

There were no significant distinctions between the patient and control groups concerning FABP2 and CRP polymorphisms (p > .05). No significant relationship was observed between studied polymorphisms and sd-LDL level in the patient group (p > .05). However, patients group had higher level of sd-LDL compared to controls (p < .05).

Conclusion

FABP2 Ala54Thr and CRP+1059G/C polymorphisms were not associated with atherosclerosis and sd-LDL level. However, the increased sd-LDL level was known as a risk factor for atherosclerosis.

中文翻译：

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FABP2 Ala54Thr 和 CRP+1059C/G 多态性与动脉粥样硬化患者小而密 LDL 水平的关联：一项病例对照研究

摘要

背景

脂肪酸结合蛋白 2 (FABP2) 和 C 反应蛋白 (CRP) 的多态性可能是动脉粥样硬化的遗传危险因素。该研究旨在探讨 FABP2 Ala54Thr 和 CRP+1059C/G 多态性与动脉粥样硬化的关系以及小密度低密度脂蛋白 (sd-LDL) 的相关性。

方法

总共包括 255 名受试者（125 名对照者和 130 名患者）。FABP2和CRP多态性分别通过PCR-RFLP和AS-PCR方法确定。Sd-LDL 的测量基于 Hirano 等人的方法。

结果

在 FABP2 和 CRP 多态性方面，患者组和对照组之间没有显着差异 ( p  > .05)。在患者组中，研究的多态性与 sd-LDL 水平之间未观察到显着关系 ( p  > .05)。然而，与对照组相比，患者组的 sd-LDL 水平更高 ( p  < .05)。

结论

FABP2 Ala54Thr 和 CRP+1059G/C 多态性与动脉粥样硬化和 sd-LDL 水平无关。然而，sd-LDL 水平升高被认为是动脉粥样硬化的危险因素。