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Green approaches for the synthesis of nucleotides, their conjugates and analogues
Phosphorus, Sulfur, and Silicon and the Related Elements ( IF 1.4 ) Pub Date : 2020-09-25 , DOI: 10.1080/10426507.2020.1804164
Lucie Appy 1 , Anaïs Depaix 1 , Xavier Bantreil 2 , Frédéric Lamaty 2 , Suzanne Peyrottes 1 , Béatrice Roy 1
Affiliation  

Abstract We have developed original one-pot and protecting group-free approaches, which are also user-friendly and reliable, to synthesize nucleotides and derivatives starting from nucleoside 5’-monophosphates. Both methods present convenient set-up, i.e., non-dry solvents and reagents, substrates in their sodium or acid form, and commercially available and cheap phosphorus reagents as sodium and potassium salts. GRAPHICAL ABSTRACT

中文翻译:

合成核苷酸、其结合物和类似物的绿色方法

摘要 我们开发了独创的一锅法和无保护基团的方法,这些方法也是用户友好和可靠的,用于从核苷 5'-单磷酸酯开始合成核苷酸和衍生物。这两种方法都具有方便的设置,即非干燥溶剂和试剂、钠或酸形式的底物,以及市售的廉价磷试剂,如钠盐和钾盐。图形概要
更新日期:2020-09-25
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