ABSTRACT

Introduction

A microneedle array patch (MAP) has been studied as a means for delivering drugs or vaccines and has shown superior delivery efficiency compared to the conventional transdermal drug delivery system (TDD). This paper reviews recent advancements in the development of MAPs, with a focus on their size, shapes, and materials in preclinical and clinical studies for pharmaceutics.

Area covered

We classified MAPs for drug delivery into four types: coated, dissolving, separable, and swellable. We covered their recent developments in materials and geometry in preclinical and clinical studies.

Expert opinion

The design of MAPs needs to be determined based on what properties would be effective for the target diseases and purposes. In addition, in preclinical studies, it is necessary to consider not only the novelty of the formulations but also the feasibility of clinical application. Currently, clinical studies of microneedles loaded with various drugs and vaccines are in progress. When the regulation of pharmaceutical microneedles is established and more clinical studies are published, more drugs will be developed as microneedle products and clinical research will proceed. With these considerations, the microneedle array patch will be a better option for drug delivery.

中文翻译：

---

用于药物输送的微针：用于临床前和临床研究的材料和几何形状的最新进展

摘要

介绍

微针阵列贴片 (MAP) 已被研究作为一种递送药物或疫苗的手段，与传统的透皮给药系统 (TDD) 相比，它显示出更高的递送效率。本文回顾了 MAP 开发的最新进展，重点介绍了它们在药物临床前和临床研究中的大小、形状和材料。

覆盖面积

我们将用于药物递送的 MAP 分为四种类型：包衣型、溶解型、可分离型和可膨胀型。我们在临床前和临床研究中介绍了他们在材料和几何形状方面的最新进展。

专家意见

MAP 的设计需要根据对目标疾病和目的有效的特性来确定。此外，在临床前研究中，不仅要考虑剂型的新颖性，还要考虑临床应用的可行性。目前，载有各种药物和疫苗的微针的临床研究正在进行中。当药用微针的监管建立起来，更多的临床研究发表后，就会有更多的药物作为微针产品开发出来，临床研究也会继续进行。考虑到这些因素，微针阵列贴片将是药物输送的更好选择。