HIF‐1α ameliorates tubular injury in diabetic nephropathy via HO‐1–mediated control of mitochondrial dynamics,Cell Proliferation

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HIF‐1α ameliorates tubular injury in diabetic nephropathy via HO‐1–mediated control of mitochondrial dynamics
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-09-25 , DOI: 10.1111/cpr.12909
Na Jiang _{1,

2} , Hao Zhao _{1,

2} , Yachun Han _{1,

2} , Li Li _{1,

2} , Shan Xiong _{1,

2} , Lingfeng Zeng _{1,

2} , Ying Xiao _{1,

2} , Ling Wei _{1,

2} , Xiaofen Xiong _{1,

2} , Peng Gao _{1,

2} , Ming Yang _{1,

2} , Yu Liu _{1,

2} , Lin Sun _{1,

2}

Affiliation

In diabetic nephropathy (DN), hypoxia‐inducible factor‐1α (HIF‐1α) activation in tubular cells plays an important protective role against kidney injury. The effects may occur via the target genes of HIF‐1α, such as haem oxygenase‐1 (HO‐1), but the exact mechanisms are incompletely understood.

中文翻译：

HIF-1α通过HO-1介导的线粒体动力学控制改善糖尿病肾病肾小管损伤

在糖尿病肾病 (DN) 中，肾小管细胞中的缺氧诱导因子 1α (HIF-1α) 激活对肾损伤起着重要的保护作用。这些影响可能通过 HIF-1α 的靶基因发生，例如血红素加氧酶-1 (HO-1)，但确切机制尚不完全清楚。

更新日期：2020-09-25

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