Synthesis, antioxidant activity, and α‐glucosidase enzyme inhibition of α‐aminophosphonate derivatives bearing piperazine‐1,2,3‐triazole moiety,Journal of Heterocyclic Chemistry

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Synthesis, antioxidant activity, and α‐glucosidase enzyme inhibition of α‐aminophosphonate derivatives bearing piperazine‐1,2,3‐triazole moiety
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-09-25 , DOI: 10.1002/jhet.4157
Madhu Kumar Reddy Kandula ₁ , Mohan Gundluru _{1,

2} , Bakthavatchala Reddy Nemallapudi ₃ , Sravya Gundala ₃ , Peddanna Kotha ₄ , Grigory V Zyryanov _{3,

5} , Sridevi Chadive ₆ , Suresh Reddy Cirandur ₁

Affiliation

A novel series of piperazine‐1,2,3‐triazole bearing dimethyl(((2‐(4‐((1H‐1,2,3‐triazole‐4‐yl)methyl)piperazin‐1‐yl)ethylamino)(2‐hydroxyaryl)methyl)phosphonate derivatives have been prepared via copper‐catalyzed azide‐alkyne 1,3‐dipolar cycloaddition (CuAAC) (Click Reaction) and Schiff base reactions. The synthesized compounds were confirmed by spectral characterization (¹H, ¹³C and ³¹P NMR, and mass). The title compounds were evaluated for in vitro alpha glucosidase enzyme inhibition and in vitro antioxidant activity using DPPH and H₂O₂ methods.

中文翻译：

带有哌嗪-1,2,3-三唑部分的α-氨基膦酸酯衍生物的合成，抗氧化剂活性和α-葡萄糖苷酶抑制作用

一系列新的带有二甲基（（（2-（4-（（（1H-1,2,3-三唑-4-基）甲基）哌嗪-1-基）乙基氨基）（通过铜催化的叠氮化物-炔烃1,3-偶极环加成（CuAAC）（点击反应）和席夫碱反应制备了2-羟基芳基）甲基）膦酸酯衍生物。合成的化合物通过光谱表征（¹ H，¹³ C和³¹ P NMR和质量）。使用DPPH和H ₂ O ₂方法评估了标题化合物的体外α葡萄糖苷酶抑制作用和体外抗氧化活性。

更新日期：2020-09-25

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