Tumor‐derived microparticles in tumor immunology and immunotherapy,European Journal of Immunology

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Tumor‐derived microparticles in tumor immunology and immunotherapy
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-09-25 , DOI: 10.1002/eji.202048548
Jingwei Ma ₁ , Huafeng Zhang ₂ , Ke Tang ₃ , Bo Huang _{3,

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Affiliation

Microvesicles or microparticles, a type of cytoplasm membrane‐derived extracellular vesicles, can be released by cancer cells or normal cell types. Alteration of F‐actin cytoskeleton by various signals may lead to the cytoplasm membrane encapsulating cellular contents to form microparticles, which contain various messenger molecules, including enzymes, RNAs and even DNA fragments, and are released to extracellular space. The release of microparticles by tumor cells (T‐MPs) is a very common event in tumor microenvironments. As a result, T‐MPs not only influence tumor cell biology but also profoundly forge tumor immunology. Moreover, T‐MPs can act as a natural vehicle that delivers therapeutic drugs to tumor cells and immune cells, thus, remodeling tumor microenvironments and resetting antitumor immune responses, thus, conferring T‐MPs a potential role in tumor immunotherapies and tumor vaccines. In this review, we focus on the double‐edged sword role of T‐MPs in tumor immunology, specifically in TAMs and DCs, and emphasize the application of drug‐packaging T‐MPs in cancer patients. We aim to provide a new angle to understand immuno‐oncology and new strategies for cancer immunotherapy.

中文翻译：

肿瘤免疫学和免疫疗法中的肿瘤来源微粒

微囊或微粒是细胞质膜衍生的细胞外囊泡的一种，可被癌细胞或正常细胞类型释放。F-肌动蛋白细胞骨架被各种信号改变可能导致细胞质膜包裹细胞内含物，形成微粒，微粒包含各种信使分子，包括酶，RNA甚至DNA片段，并释放到细胞外空间。肿瘤细胞（T-MP）释放微粒是肿瘤微环境中非常普遍的事件。结果，T-MPs不仅影响肿瘤细胞生物学，而且深刻地增强了肿瘤免疫学。此外，T-MP可以充当天然载体，向肿瘤细胞和免疫细胞输送治疗药物，从而重塑肿瘤微环境并重设抗肿瘤免疫反应，因此，赋予TMPs在肿瘤免疫疗法和肿瘤疫苗中的潜在作用。在这篇综述中，我们着眼于T-MP在肿瘤免疫学中的双刃剑作用，特别是在TAM和DC中，并强调了药物包装T-MP在癌症患者中的应用。我们旨在提供一个新的角度来了解免疫肿瘤学和癌症免疫疗法的新策略。

更新日期：2020-11-06

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