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Temporary/Permanent Dual Cross-Link Gels Formed of a Bioactive Lactose-Modified Chitosan.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-09-25 , DOI: 10.1002/mabi.202000236 Pasquale Sacco 1 , Franco Furlani 1 , Andrea Marfoglia 1 , Michela Cok 1 , Chiara Pizzolitto 2 , Eleonora Marsich 2 , Ivan Donati 1
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-09-25 , DOI: 10.1002/mabi.202000236 Pasquale Sacco 1 , Franco Furlani 1 , Andrea Marfoglia 1 , Michela Cok 1 , Chiara Pizzolitto 2 , Eleonora Marsich 2 , Ivan Donati 1
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Mounting evidences have recognized that dual cross‐link and double‐network gels can promisingly recapitulate the complex living tissue architecture and overcome mechanical limitations of conventional scaffolds used hitherto in regenerative medicine. Here, dual cross‐link gels formed of a bioactive lactose‐modified chitosan reticulated via both temporary (boric acid‐based) and permanent (genipin‐based) cross‐linkers are reported. While boric acid rapidly binds to lactitol flanking diols increasing the overall viscosity, a slow temperature‐driven genipin binding process takes place allowing for network strengthening. Combination of frequency and stress sweep experiments in the linear stress–strain region shows that ultimate gel strength, toughness, and viscoelasticity depend on polymer‐to‐genipin molar ratio. Notably, herewith it is demonstrated that linear stretching correlates with strain energy dissipation through boric acid binding/unbinding dynamics. Strain‐hardening effect in the nonlinear regime, along with good biocompatibility in vitro, points at an interesting role of present system as biological extracellular matrix substitute.
中文翻译：
由生物活性乳糖改性壳聚糖形成的临时/永久双交联凝胶。
越来越多的证据已经认识到，双交联和双网络凝胶可以很好地概括复杂的活组织结构，并克服迄今为止在再生医学中使用的传统支架的机械局限性。在这里，报告了由生物活性乳糖改性壳聚糖通过临时（基于硼酸）和永久（基于京尼平）交联剂形成网状结构的双交联凝胶。虽然硼酸迅速与乳糖醇侧翼二醇结合，增加了整体粘度，但会发生缓慢的温度驱动京尼平结合过程，从而加强网络。线性应力-应变区域中频率和应力扫描实验的组合表明，极限凝胶强度、韧性和粘弹性取决于聚合物与京尼平的摩尔比。尤其，由此证明线性拉伸与通过硼酸结合/解结合动力学的应变能耗散相关。非线性状态下的应变硬化效应，以及良好的体外生物相容性，表明本系统作为生物细胞外基质替代品的有趣作用。
更新日期：2020-09-25
中文翻译：
由生物活性乳糖改性壳聚糖形成的临时/永久双交联凝胶。
越来越多的证据已经认识到，双交联和双网络凝胶可以很好地概括复杂的活组织结构，并克服迄今为止在再生医学中使用的传统支架的机械局限性。在这里，报告了由生物活性乳糖改性壳聚糖通过临时（基于硼酸）和永久（基于京尼平）交联剂形成网状结构的双交联凝胶。虽然硼酸迅速与乳糖醇侧翼二醇结合，增加了整体粘度，但会发生缓慢的温度驱动京尼平结合过程，从而加强网络。线性应力-应变区域中频率和应力扫描实验的组合表明，极限凝胶强度、韧性和粘弹性取决于聚合物与京尼平的摩尔比。尤其，由此证明线性拉伸与通过硼酸结合/解结合动力学的应变能耗散相关。非线性状态下的应变硬化效应，以及良好的体外生物相容性，表明本系统作为生物细胞外基质替代品的有趣作用。
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