Testicular leiomyomas and gonadal dysfunctions are not commonly reported in teleost and particularly in broodstock fish. In the present work, a testicular leiomyoma related to an unusual case of spermatogenic failure syndrome, in a broodstock seabass coming from an Italian aquaculture farm, is reported. At gross pathology, the circumscribed neoplasia showed several white nodular masses, originating from the gonad, deforming the anatomo‐physiological shape. From light microscopy, the presence of neoplastic tissue islands with spindle cells with a whirling pattern and the low presence of connective tissue were evident and originated from smooth muscle cells. Seminiferous tubules showed severe azoospermia with the absence of sperm cells even closer to the neoplastic area. Immunohistochemical analysis was positive for alpha‐SMA, desmin and vimentin but negative for S‐100, confirming a diagnosis of leiomyoma. This is the first report of spermatogenic failure syndrome associated with a testicular leiomyoma in fish from broodstock. More efforts should be made in studying broodstock fish pathologies related to fish maintenance and hormonal treatments that could economically affect aquaculture production.

中文翻译：

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亲鱼鲈鱼的睾丸平滑肌瘤和生精失败综合征

在硬骨鱼中，尤其是亲鱼中，睾丸平滑肌瘤和性腺功能障碍的报道并不普遍。在目前的工作中，据报道在来自意大利水产养殖场的亲鱼鲈鱼中，与罕见的生精失败综合症有关的睾丸平滑肌瘤。在大体病理学上，外切性瘤形成有几个白色的结节性肿块，起源于性腺，使解剖生理形状变形。从光学显微镜观察，明显可见带有梭形细胞梭形细胞的赘生性组织岛的存在和结缔组织的低存在，其起源于平滑肌细胞。曲细精管表现出严重的无精症，甚至在靠近肿瘤区域的地方没有精子细胞。免疫组织化学分析为α-SMA阳性，结蛋白和波形蛋白但对S-100阴性，证实诊断为平滑肌瘤。这是亲鱼鱼类睾丸平滑肌瘤引起的生精失败综合征的首次报道。在研究与鱼类养护和激素处理有关的亲鱼病理学方面，应做出更多努力，这可能会在经济上影响水产养殖的生产。