Choosing the right essential oil for a mouthwash: chemical, antimicrobial and cytotoxicity study,Chemistry & Biodiversity

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Choosing the right essential oil for a mouthwash: chemical, antimicrobial and cytotoxicity study
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-11-01 , DOI: 10.1002/cbdv.202000748
Gordana Filipović ₁ , Milica D Stevanović ₂ , Zorica Stojanović-Radić ₃ , Radmila Obradović ₄ , Pavle J Randjelović ₅ , Niko S Radulović ₂

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Thirteen commercial essential oils were assessed for their possible inclusion in a mouthwash formulation based on their inhibitory effect against potentially pathogenic anaerobic oral bacterial isolates from subgingival plaque, and their cytotoxicity towards gingival cells. The essential oils, originating from species belonging to seven major aromatic plant families, were chosen to provide the necessary diversity in chemical composition that was analyzed in detail by GC and GC/MS. Multivariate statistical analysis, performed using the in vitro microbiological/toxicological assays and compositional data, revealed that the major components of the essential oils were probably not the main carriers of the activities observed. A formulation of ‘designer’ mouthwashes is proposed based on the selective action of certain essential oils towards specific bacterial isolates (e. g., Citrus bergamia vs. Parvimonas micra), and non‐toxicity to gingival cells at antimicrobially active concentrations.

中文翻译：

为漱口水选择合适的精油：化学、抗菌和细胞毒性研究

评估了 13 种商业精油可能包含在漱口剂配方中的可能性，这是基于它们对来自龈下菌斑的潜在致病性厌氧口腔细菌分离物的抑制作用，以及它们对牙龈细胞的细胞毒性。精油来自属于七个主要芳香植物科的物种，被选中以提供必要的化学成分多样性，并通过 GC 和 GC/MS 进行详细分析。使用体外微生物学/毒理学试验和成分数据进行的多变量统计分析表明，精油的主要成分可能不是所观察到的活性的主要载体。

更新日期：2020-11-01

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