Calcium ATPase signaling: A must include mechanism in the radar of therapeutics development against tuberculosis,Biotechnology and Applied Biochemistry

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Calcium ATPase signaling: A must include mechanism in the radar of therapeutics development against tuberculosis
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-09-25 , DOI: 10.1002/bab.2038
Shivangi _{1,

2} , Laxman S Meena _{1,

2}

Affiliation

An article presented by Peterson and Verkhratsky in 2016 explores the linkage of calcium and adenosine triphosphate (ATP) for a themed issue of Evolution Brings Ca²⁺ and ATP Together to Control Life and Death. The article impacted due to several findings of their cooperative functioning such as the formulation of ATP necessitates a small concentration of cytosolic Ca²⁺, and therefore leads these two molecules together. The low cytosolic Ca²⁺ concentration is a primary advantage of its function like a universal secondary messenger. The present article also explores the essential facts about Ca²⁺–ATP signaling in response to tuberculosis (TB). TB is still a major causal mortality of an important fraction of worldwide population and therefore we require an urgent regimen for its treatment. The new strategies that cover all forms of the disease multidrug-resistant TB, extensively drug-resistant TB, and TDR are necessity to overcome the disease pattern and its outcomes. Ionophores and channels-mediated transportation of Ca²⁺ that leads to the elevation of intracellular Ca²⁺ concentration provides an important clue to divert the focus toward this signaling mechanism. P2X7 pathway is an enormous Ca²⁺ signaling pathway that incorporated Ca²⁺ influx and potassium efflux upon activation by ATP molecule. After this activation, immune components like 1L-12 and IL-6 release and generate a protective response against pathogen. This review highlights importance of togetherness of Ca²⁺ and ATP signaling with new and more emphasized view of Ca²⁺ regulation.

中文翻译：

钙 ATP 酶信号传导：结核病治疗开发雷达中必须包含的机制

Peterson 和 Verkhratsky 在 2016 年发表的一篇文章探讨了钙和三磷酸腺苷 (ATP) 之间的联系，其主题为“进化将 Ca ²⁺和 ATP 结合起来控制生命和死亡” 。这篇文章之所以产生影响，是因为它们的协同功能的一些发现，例如 ATP 的形成需要低浓度的胞质 Ca ²⁺ ，因此将这两个分子结合在一起。低胞质 Ca ²⁺浓度是其作为通用第二信使的功能的主要优势。本文还探讨了 Ca ²⁺ –ATP 信号传导对结核病 (TB) 的反应的基本事实。结核病仍然是世界上很大一部分人口的主要死因，因此我们需要紧急的治疗方案。涵盖所有形式的耐多药结核病、广泛耐药结核病和 TDR 的新策略对于克服疾病模式及其结果是必要的。离子载体和通道介导的 Ca ²⁺运输导致细胞内 Ca ²⁺浓度升高，为将焦点转移到这种信号机制提供了重要线索。 P2X7 途径是一条巨大的Ca ²⁺信号传导途径，在ATP 分子激活后整合Ca ²⁺流入和钾流出。激活后，1L-12 和 IL-6 等免疫成分释放并产生针对病原体的保护性反应。这篇综述强调了 Ca ²⁺和 ATP 信号传导结合的重要性以及 Ca ²⁺调节的新的、更强调的观点。

更新日期：2020-09-25

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