Abstract Biosensor technology is a quite attractive and rapidly developing research field in recent years, and the sub field of optical photonic crystal (PC) biosensor based on label free sensing technology has also made great progress in this period. This review mainly concentrates on advances in the label free refractometric sensing based two dimensional (2D) PC slab biosensors particularly in the last decade, emphasizing the development and evolution of structural design. It begins with a brief discussion on the basic principles and design methods of label free 2D PC biosensors. Then, the sensors are classified according to the designed geometric structure and research progress of various sensors is reviewed, highlighting efforts dedicated to improving the transducer configuration and integration. Additionally, surface functionalization methods for different materials to produce reproducible surface properties and different detection methods for biological targets are introduced for evaluation. 2D PC refractometric biosensors have been applied to a great many applications varying from biotechnology, food safety, water quality monitoring to clinical diagnosis. Finally, the authors’ views on current limitations of the slab for biosensing as well as the optimizable aspects are presented.

中文翻译：

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使用无标签折光传感方案的二维光子晶体板生物传感器：综述

摘要 生物传感器技术是近年来极具吸引力且发展迅速的研究领域，基于无标记传感技术的光学光子晶体（PC）生物传感器子领域也在这一时期取得了长足的进步。这篇综述主要集中在基于无标记折光传感的二维 (2D) PC 平板生物传感器的进展，特别是在过去十年中，强调结构设计的发展和演变。首先简要讨论无标记 2D PC 生物传感器的基本原理和设计方法。然后，根据设计的几何结构对传感器进行分类，并回顾了各种传感器的研究进展，重点介绍了致力于改进传感器配置和集成的努力。此外，介绍了用于不同材料的表面功能化方法以产生可重复的表面特性以及对生物目标的不同检测方法进行评估。2D PC 折光生物传感器已应用于从生物技术、食品安全、水质监测到临床诊断的众多应用中。最后，作者对生物传感平板目前的局限性以及可优化方面提出了看法。