Prepulse inhibition (PPI) is a neurological phenomenon in which a weak initial stimulus reduces the level of responses to a subsequent stronger stimulus. Although acoustic startle reflexes are usually used for PPI examinations, recent studies have observed similar phenomena with event-related cortical potentials. In the present study, test-retest reliability of PPI measured using auditory change-related cortical responses was assessed in 35 healthy adults. Four sound stimuli were randomly presented at an even probability; Standard, Test alone, Prepulse alone, and Test + Prepulse. The Standard stimulus was a train of 25-ms tone pulses at 70 dB for 650 ms, while for Test alone and Prepulse alone, the sound pressure was increased to 80 dB at 350 ms and 73 dB at 300 ms, respectively. Measurements were performed twice with at least 7 days separation, and validity was evaluated using intra-class correlation (ICC) for latency, amplitude, and suppression rate of the P50, N100, and P200 components. The results showed high ICC values for the latency and amplitude of nearly all components, except for response to Prepulse alone (0.3–0.6). Furthermore, ICC for suppression rate was greater than 0.5 for the peak-to-peak amplitude. Good reproducibility for N100 and P200 components was obtained with this method. The present results support the PPI paradigm as a reliable tool for clinical measurements of inhibitory functions.

前脉冲抑制 (PPI) 是一种神经学现象，其中较弱的初始刺激会降低对后续更强刺激的反应水平。尽管听觉惊吓反射通常用于 PPI 检查，但最近的研究已经观察到与事件相关的皮层电位类似的现象。在本研究中，在 35 名健康成人中评估了使用与听觉变化相关的皮层反应测量的 PPI 的重测信度。四种声音刺激以偶数概率随机呈现；标准、单独测试、单独预脉冲和测试 + 预脉冲。标准刺激是一串 25 ms 音调脉冲，70 dB 持续 650 ms，而对于单独的 Test 和单独的 Prepulse，声压分别在 350 ms 和 300 ms 时增加到 80 dB 和 73 dB。测量进行两次，至少间隔 7 天，使用类内相关性 (ICC) 评估 P50、N100 和 P200 分量的延迟、幅度和抑制率的有效性。结果显示，除了对 Prepulse 的单独响应 (0.3–0.6) 之外，几乎所有组件的延迟和振幅都具有高 ICC 值。此外，抑制率的ICC对于峰峰值幅度大于0.5。使用此方法可获得 N100 和 P200 组分的良好重现性。目前的结果支持 PPI 范式作为抑制功能临床测量的可靠工具。此外，抑制率的ICC对于峰峰值幅度大于0.5。使用此方法可获得 N100 和 P200 组分的良好重现性。目前的结果支持 PPI 范式作为抑制功能临床测量的可靠工具。此外，抑制率的ICC对于峰峰值幅度大于0.5。使用此方法可获得 N100 和 P200 组分的良好重现性。目前的结果支持 PPI 范式作为抑制功能临床测量的可靠工具。