Recent studies have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. Also, numerous lines of evidence have indicated that inflammatory processes are involved in the pathogenesis of Parkinson’s disease (PD). We have examined whether single nucleotide polymorphisms at the genes encoding chemokines RANTES (-28 C > G), RANTES (-403 A > G) MCP-1 (-2518 A > G), and chemokine receptors CCR2 (+190 G > A) and CCR5 (-Δ32) were associated with sporadic PD risk in the Indian population. This pilot case-control association study included 97 PD patients and 100 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms. There was no statistically significant difference in the genotype frequencies between the cases and controls for the MCP1 (-2518 A > G), RANTES (-403 A > G) and CCR2 (+190 G > A) polymorphisms. However, the results revealed a significant difference in the frequency of the heterozygous CG genotype for the RANTES (-28 C > G) polymorphism (OR = 0.49, p = 0.03) between the cases and controls. A negative association was demonstrated in the dominant model where, compared with the GG genotype, a higher frequency of the GC + CC genotype was observed in the controls. Also, a statistically significant higher frequency of the CCR5 heterozygous genotype WT/Δ32 in the controls was observed (OR = 0.31, p = 0.04). Combined genotype analysis revealed that the allele combination of G-A-G-C of CCR2 (+190G > A), MCP-1 (-2518 A/G), RANTES (-403 A/G) and RANTES (-28 C/G) respectively had a risk association with PD (OR = 6.18, p = 0.005).

最近的研究表明趋化因子及其受体与几种神经退行性疾病有关。另外，大量证据表明炎症过程与帕金森氏病（PD）的发病机理有关。我们检查了编码趋化因子RANTES（-28 C> G），RANTES（-403 A> G）MCP-1（-2518 A> G）和趋化因子受体CCR2（+190 G> A ）的基因的单核苷酸多态性）和CCR5（-Δ32）与印度人群中散发的PD风险相关。这项病例对照试验研究包括97名PD患者和100名对照受试者，他们均通过PCR-RFLP进行了5种多态性的基因分型。在病例和对照之间，MCP1（-2518 A> G），RANTES（-403 A> G）和CCR2（ +190 G> A）多态性在基因型频率上没有统计学上的显着差异。但是，结果显示RANTES杂合CG基因型的频率存在显着差异病例与对照组之间的（-28 C> G）多态性（OR = 0.49，p = 0.03）。在显性模型中显示出负相关，其中与GG基因型相比，在对照中观察到更高频率的GC + CC基因型。而且，在对照中观察到CCR5杂合基因型WT /Δ32的统计学上显着较高的频率（OR ＝ 0.31，p ＝ 0.04）。联合基因型分析显示，CCR2（ + 190G> A），MCP-1（-2518 A / G），RANTES（-403 A / G）和RANTES（-28 C / G）的GAGC等位基因组合分别具有与PD的风险相关（OR = 6.18，p = 0.005）。