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Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm
Journal of Structural Biology ( IF 3.0 ) Pub Date : 2020-09-25 , DOI: 10.1016/j.jsb.2020.107631
Jonas Palle 1 , Nina Kølln Wittig 1 , Adam Kubec 2 , Sven Niese 3 , Martin Rosenthal 4 , Manfred Burghammer 4 , Tilman A Grünewald 4 , Henrik Birkedal 1
Affiliation  

Studying nanostructured hierarchical materials such as the biomineralized bone is challenging due to their complex 3D structures that call for high spatial resolution. One route to study such materials is X-ray powder diffraction computed tomography (XRD-CT) that reveals the 3D distribution of crystalline phases and X-ray fluorescence computed tomography (XRF-CT) that provides element distributions. However, the spatial resolution of XRD-CT has thus far been limited. Here we demonstrate better than 120 nm 3D resolution on human bone in XRD-CT and XRF-CT measured simultaneously using X-ray nanobeams. The results pave the way for nanoscale 3D characterization of nanocrystalline composites like bone at unprecedented detail.



中文翻译:

对人体骨骼进行纳米束 X 射线荧光和衍射计算机断层扫描,分辨率优于 120 nm

由于其复杂的 3D 结构需要高空间分辨率,因此研究纳米结构分层材料(例如生物矿化骨)具有挑战性。研究此类材料的一种途径是 X 射线粉末衍射计算机断层扫描 (XRD-CT),它揭示了晶相的 3D 分布,以及提供元素分布的 X 射线荧光计算机断层扫描 (XRF-CT)。然而,迄今为止,XRD-CT 的空间分辨率受到限制。在这里,我们在使用 X 射线纳米束同时测量的 XRD-CT 和 XRF-CT 中证明了人体骨骼的 3D 分辨率优于 120 nm。结果为以前所未有的细节对骨骼等纳米晶复合材料进行纳米级 3D 表征铺平了道路。

更新日期:2020-10-02
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