Abstract Two wheel-shaped lanthanide complexes, [Pr(L)2•(CH3OH)2]•(NO3)3 (complex 1) and [Er(L)2•(CH3OH)2]•(NO3)3 (compex 2), formed by the long flexible ligand, (L = 1,4-bis[2-(4-pyridyl)ethenyl]benzene), were synthesized and characterized. The interaction of the complexes 1-2 with FS-DNA was explored using UV absorption spectra and fluorescence spectra demonstrating the bind to DNA in partial insertion. The ability of complex 1-2 to react with pBR322 plasmid DNA was confirmed by gel electrophoresis, showing that complex 1 had a better cutting effect. Apoptosis research experiments showed that the complex significantly inhibited the growth of HeLa cells. In addition, MTT analysis evaluated the anticancer ability of the two complexes, and the results showed that complex 1 had a better inhibitory effect on HeLa cells, and molecular docking technology was used to simulate the binding of the complex to DNA.

中文翻译：

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具有长柔性配体的两个轮状 Pr(III) 和 Er(III) 配合物：晶体结构、荧光和抗癌研究

摘要 两个轮状镧系元素络合物，[Pr(L)2•(CH3OH)2]•(NO3)3（络合物 1）和 [Er(L)2•(CH3OH)2]•(NO3)3（络合物 2） )，由长的柔性配体形成，(L = 1,4-双[2-(4-吡啶基)乙烯基]苯)，被合成和表征。使用紫外吸收光谱和荧光光谱探索了复合物 1-2 与 FS-DNA 的相互作用，表明在部分插入中与 DNA 结合。凝胶电泳证实了复合物1-2与pBR322质粒DNA反应的能力，表明复合物1具有较好的切割效果。凋亡研究实验表明，该复合物显着抑制了HeLa细胞的生长。此外，MTT分析评估了两种配合物的抗癌能力，结果表明配合物1对HeLa细胞有较好的抑制作用，