Our study investigated a large variety of per- and polyfluoroalkyl substances (PFASs) in house dust collected from Guangzhou, South China during 2015–2018. The perfluorobutane sulfonic acid (PFBS) exhibited the highest median concentration (17.6 ng/g), followed by linear perfluorooctanoic acid (L-PFOA; 4.8 ng/g), linear perfluorooctane sulfonic acid (L-PFOS; 4.2 ng/g), 6:2 fluorotelomer phosphate diester (6:2 diPAP; 3.4 ng/g), perfluorodecanoic acid (PFDA; 1.2 ng/g) and perfluoroundecanoic acid (PFUdA; 1.2 ng/g), and 6:2 chlorinated perfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA; 1.1 ng/g). Total concentrations of PFASs (median: 53 ng/g) were generally within the 25–50 percentile of the concentration range reported in global studies. However, our samples exhibited composition profiles different from those reported in many other regions. Analysis based on this and previous studies revealed that the compositions in house dust from East Asia, North America, and Europe exhibit a region-specific pattern. This may indicate region-specific market demands, application patterns, as well as associated human exposure risks. Exploration of dwelling characterizations suggested that renovation history appeared to be a significant factor influencing PFAS concentrations in house dust, although other factors may exist and play a role. Estimation of daily intakes via dust ingestion and dermal contact indicates low exposure risks from these two pathways. However, the PFAS chemical-specific biological effects, possible mixture effects, as well as additional exposure pathways, imply that the risk from indoor PFAS exposure should not be overlooked.

我们的研究调查了2015-2018年间从华南广州收集的房屋灰尘中的各种全氟烷基物质和多氟烷基物质（PFAS）。全氟丁烷磺酸（PFBS）的中位浓度最高（17.6 ng / g），其次是线性全氟辛酸（L-PFOA; 4.8 ng / g），线性全氟辛烷磺酸（L-PFOS; 4.2 ng / g）， 6：2氟代端粒磷酸二酯（6：2 diPAP; 3.4 ng / g），全氟癸酸（PFDA; 1.2 ng / g）和全氟十一酸（PFUdA; 1.2 ng / g）和6：2氯化全氟烷基醚磺酸（ 6：2 Cl-PFESA； 1.1 ng / g）。PFAS的总浓度（中位数：53 ng / g）通常在全球研究报告的浓度范围的25-50％范围内。但是，我们的样品显示出与许多其他地区所报道的成分不同的成分曲线。根据这项研究和以前的研究进行的分析表明，来自东亚，北美和欧洲的房屋扬尘组成具有特定区域的规律。这可能表明特定地区的市场需求，应用模式以及相关的人类暴露风险。对住宅特征的探索表明，装修历史似乎是影响房屋扬尘中PFAS浓度的重要因素，尽管可能存在其他因素并发挥作用。通过粉尘摄入和皮肤接触估计每日摄入量表明这两种途径的低暴露风险。但是，PFAS的化学特异性生物效应，可能的混合物效应以及其他暴露途径暗示着，不应忽视室内PFAS暴露的风险。