Obesity rates are increasing globally, and recent theories suggest that phthalates may contribute to obesity development. This longitudinal study aimed to investigate associations between environmental phthalate exposure during childhood and obesity, utilizing data from 100 participants from a Swedish birth cohort. The participants were followed repeatedly from birth and provided spot urine samples at 4 years. Weight and height were measured at ages 4, 8, 16 and 24 years, as well as additional anthropometric indices at 24 years. Urine samples were analysed for 10 phthalate metabolites using liquid chromatography tandem mass spectrometry. Generalized estimating equation models were performed to assess overall and age-specific associations between urinary phthalate concentrations and BMI groups; thin/normal weight vs overweight/obese. After adjustment for potential confounders, overall associations were observed for diisononyl phthalate (DiNP) metabolites mono(oxo-isononyl) phthalate (MOiNP) (OR per increase ng/ml: 1.18; 95% CI: 1.05, 1.33), mono(carboxy-isooctyl) phthalate (MCiOP) (OR: 1.06; 95% CI: 1.01, 1.11) and ∑DiNP (OR: 1.02; 95% CI:1.00, 1.04) and development of overweight/obesity up to age 24 years. Age-specific associations were observed for the same metabolites at 8, 16 and 24 years. Furthermore, linear regression analysis revealed associations between increased body fat % at age 24 years and MHiNP (β: 2.42; 95% CI: 0.44, 4.39), MOiNP (β: 2.32; 95% CI: 0.46, 4.18), MCiOP (β: 2.65; 95% CI: 0.41, 4.89) and ∑DiNP (β: 2.65; 95% CI: 0.52, 4.77). These findings suggest that DiNP exposure during preschool age may be associated with subsequent obesity, however these findings need to be corroborated by further research.

肥胖率在全球范围内正在增加，并且最近的理论表明邻苯二甲酸盐可能有助于肥胖症的发展。这项纵向研究旨在利用瑞典出生队列的100名参与者的数据，调查儿童时期环境邻苯二甲酸酯暴露与肥胖之间的关系。从出生开始就反复跟踪参与者，并在4岁时提供尿液样本。在4、8、16和24岁时测量体重和身高，并在24岁时测量其他人体测量指标。使用液相色谱串联质谱法分析尿液样品中的10种邻苯二甲酸酯代谢物。进行了广义估计方程模型，以评估尿中邻苯二甲酸酯浓度与BMI组之间的​​总体关联和特定年龄关联；瘦/正常体重与超重/肥胖。调整潜在混杂因素后，观察到邻苯二甲酸二异壬基酯（DiNP）代谢产物邻苯二甲酸单（氧代异壬基）（MOiNP）的整体关联性（或每增加ng / ml：1.18； 95％CI：1.05、1.33），单（羧基-邻苯二甲酸异辛基酯（MCiOP）（OR：1.06; 95％CI：1.01，1.11）和∑DiNP（OR：1.02; 95％CI：1.00，1.04），直至24岁为止都会出现超重/肥胖。在8、16和24岁时观察到相同代谢物的年龄特异性关联。此外，线性回归分析显示24岁时体脂增加百分比与MHiNP（β：2.42; 95％CI：0.44，4.39），MOiNP（β：2.32; 95％CI：0.46，4.18），MCiOP（β ：2.65； 95％CI：0.41、4.89）和∑DiNP（β：2.65； 95％CI：0.52、4.77）。这些发现表明，学龄前儿童接触DiNP可能与随后的肥胖有关，