There is a dire need for development of efficient and sensitive methods to efficiently screen parabens. In this research, we focused on quantification of four parabens (i.e., methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butyl paraben (BP)) using chitosan intercalated nickel/iron layered double hydroxide (CS–Ni/Fe-LDH) composites as solid phase extraction sorbent prior to HPLC-PDA analysis. CS-Ni/Fe LDH composites with a heterogeneous, porous texture, and coral reef-like structure exhibit appealing extraction efficiency for the target parabens due to the enhanced possibility for the formation of hydrogen bonding and hydrophobic interactions. The performance of the composites was assessed and optimized for solid phase extraction of parabens from standard samples and real samples (rose water, cream, toothpaste, hair serum, and sunscreen). The LDH-SPE-HPLC method exhibited a wide linear range (e.g., 100–50,000 ng L⁻¹), good linearity (R² ≥ 0.999), and good precision (relative standard deviation (RSD) < 3%). This method successfully enriched selected parabens with remarkable recovery above 85.95% and a good RSD (0.01–2.90%). The quantitation of MP, EP, PP, and BP was made at detection range (and limits of detection (LOD)) of 5–15 (9.8), 11–21 (16.2), 6–18 (12.4), and 10–20 (15.6) ng L⁻¹, respectively. The prepared composites also displayed excellent performance with enhanced reusability/durability (n = 30 cycles) and reproducibility (n = 5).

迫切需要开发有效和敏感的方法来有效地筛选对羟基苯甲酸酯。在这项研究中，我们重点研究了使用壳聚糖插层的镍/铁层状双氢氧化物（CS-Ni /）对四种对羟基苯甲酸酯（即对羟基苯甲酸甲酯（MP），对羟基苯甲酸乙酯（EP），对羟基苯甲酸丙酯（PP）和对羟基苯甲酸丁酯（BP））进行定量的方法。 Fe-LDH）复合材料作为固相萃取吸附剂，然后进行HPLC-PDA分析。具有异质多孔结构和珊瑚礁样结构的CS-Ni / Fe LDH复合材料由于增加了形成氢键和疏水作用的可能性，因此对目标对羟基苯甲酸酯具有吸引人的提取效率。评估并优化了复合材料的性能，以便从标准样品和实际样品（玫瑰水，乳霜，牙膏，头发精华，和防晒霜）。LDH-SPE-HPLC方法显示出较宽的线性范围（例如，100–50,000 ng L^-1），良好的线性度（R ²  ≥0.999），和良好的精度（相对标准偏差（RSD）<3％）。该方法成功富集了精选的对羟基苯甲酸酯，回收率显着高于85.95％，RSD良好（0.01–2.90％）。MP，EP，PP和BP的定量检测范围为5–15（9.8），11–21（16.2），6–18（12.4）和10–10的检测范围（和检测限（LOD））。分别为20（15.6）ng L ^-1。制备的复合材料还表现出优异的性能，并具有增强的可重复使用性/耐久性（n = 30个循环）和可再现性（n = 5）。