Abstract

The antimicrobial and antioxidant activity of synthesized biologically active compounds have been evaluated in comparison with the standard antioxidant, ascorbic acid. The antioxidant activity of the compounds has been studied by their ability to interact with the 2,2-diphenyl-1-picrylhydrazyl radical (\({\text{DPP}}{{{\text{H}}}^{\centerdot }}\)). The proposed test system has revealed the pronounced antiradical activity of 2-(2-hydroxybenzoyl)-N-phenylhydrazinecarbothioamide (1) (IC₅₀(DPPH) = 15.5 μM) and 2-(4-hydroxybenzoyl)N-phenylhydrazinecarbothiamide (2) (IC₅₀(DPPH) = 31.7 μM). A weak antibacterial activity of these compounds has been shown against gram-positive and gram-negative test strains.

中文翻译：

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硫代半乳糖苷和羟基苯甲酸的1,2,4-三唑衍生物的抗自由基和抗菌活性

摘要

与标准抗氧化剂抗坏血酸相比，已评估了合成生物活性化合物的抗微生物和抗氧化活性。已通过化合物与2,2-二苯基-1-picylhydrazyl自由基（\（{\ text {DPP}} {{{\ text {H}}} ^ {\ centerdot }} \））。拟议的测试系统已经揭示了2-（2-羟基苯甲酰基）-N-苯基肼基碳硫代酰胺（1）（IC ₅₀（DPPH）= 15.5μM ）和2-（4-羟基苯甲酰基）N-苯基肼基碳硫代酰胺（2）（ IC ₅₀（DPPH）= 31.7μM）。这些化合物对革兰氏阳性和革兰氏阴性测试菌株显示出弱的抗菌活性。