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An Eco-Friendly Synthesis of Some Novel Chromene-Based Heterocyclic Compounds of Biological Interest
Russian Journal of Bioorganic Chemistry ( IF 1.1 ) Pub Date : 2020-07-01 , DOI: 10.1134/s1068162020040135
E. Mansour , E. M. Nassar , A. F. El-Farargy , F. M. Abdelrazek

The target chromonylchalcone 3-(3-(4-oxo-4H-chromen-3-yl)-acryloyl)-2H-chromen-2-one was synthesized by reacting 3-acetylcoumarin with 3-formylchromone. The chromonylchalcone was reacted with active methylene reagents, thiourea, hydrazines, aromatic amines, and sodium azide to afford new heterocyclic compounds. The newly prepared compounds were screened for their anti-microbial and anti-inflammatory activities.

中文翻译:

一些具有生物意义的新型铬烯杂环化合物的生态友好合成

目标chromonylchalcone 3-(3-(4-oxo-4H-chromen-3-yl)-丙烯酰基)-2H-chromen-2-one 是通过 3-乙酰香豆素与 3-formylchromone 反应合成的。色酮查尔酮与活性亚甲基试剂、硫脲、肼、芳香胺和叠氮化钠反应生成新的杂环化合物。筛选新制备的化合物的抗微生物和抗炎活性。
更新日期:2020-07-01
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