Structural and Functional Diversity Among the Members of CTR, the Membrane Copper Transporter Family,The Journal of Membrane Biology

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Structural and Functional Diversity Among the Members of CTR, the Membrane Copper Transporter Family
The Journal of Membrane Biology ( IF 2.3 ) Pub Date : 2020-09-25 , DOI: 10.1007/s00232-020-00139-w
Taniya Mandal ₁ , Sumanta Kar ₁ , Saptarshi Maji ₁ , Samarpita Sen ₁ , Arnab Gupta ₁

Affiliation

Abstract

Copper is crucial for carrying out normal physiological functions in all higher life forms. Copper Transporter 1 (CTR1) is the high-affinity copper importer found in all eukaryotic organisms. The copper transporter family primarily comprises ~ six members (CTR1-6) and the related members share high sequence homology with CTR. However, with the exception of CTR1, not all six CTRs are present in every organism. Despite having a simple trimeric channel structure, CTR1 and other members exhibit some unique regulatory properties. In the present review, we attempt to understand the diversity and similarity of regulation and functioning of the members of this copper transporter family.

Graphic Abstract

中文翻译：

CTR 成员的结构和功能多样性，膜铜转运蛋白家族

摘要

铜对于在所有高等生命形式中执行正常生理功能至关重要。铜转运蛋白 1 (CTR1) 是在所有真核生物中发现的高亲和力铜进口蛋白。铜转运蛋白家族主要包括约 6 个成员 (CTR1-6)，相关成员与 CTR 具有高度序列同源性。然而，除了 CTR1 之外，并非所有六个 CTR 都存在于每个生物体中。尽管具有简单的三聚体通道结构，但 CTR1 和其他成员表现出一些独特的调节特性。在本综述中，我们试图了解该铜转运蛋白家族成员的调节和功能的多样性和相似性。

图形摘要

更新日期：2020-09-25

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