Abstract—The aim of the study was to establish the effect of experimental chronic circulatory failure on the levels of biogenic monoamines, their precursors, and their metabolites in rat brain structures. Thirteen weeks after experimental narrowing of the abdominal aorta to 1 or 0.7 mm, the levels of biogenic monoamines, their precursors, metabolites, kynurenine, and kynurenic acid were measured by reverse phase HPLC in rat brain structures. It was found that circulatory failure is accompanied by a decrease in the synthesis and functional activity of a mediator in the serotonergic system, which was evaluated using the level of the final metabolite 5-hydroxyindoleacetic acid. In the cerebral hemispheres, this may be partially related to deficiency of the precursor. The activation of kynurenic acid synthesis in the cerebral hemispheres and the brain stem is also likely. Changes in the indices that characterize central catecholaminergic systems were less pronounced.

摘要这项研究的目的是确定实验性慢性循环衰竭对大鼠脑结构中生物单胺，其前体及其代谢产物水平的影响。实验性腹主动脉缩窄至1或0.7 mm后的13周，通过反相HPLC测定大鼠脑结构中生物单胺，其前体，代谢产物，犬尿氨酸和犬尿酸的水平。发现循环衰竭伴随着血清素能系统中介体的合成和功能活性的降低，这是使用最终代谢物5-羟基吲哚乙酸的水平来评估的。在脑半球中，这可能部分与前体的缺乏有关。脑半球和脑干中犬尿酸合成的活化也是可能的。表征中央儿茶酚胺能系统的指数变化不太明显。