Abstract

The effect of the drug Stimforte on infection by the Hepatitis C virus (HCV) has been studied. Stimforte partially inhibits HCV infection at a dose of 100 μg/mouse and almost completely at a dose of 300 μg/mouse within 24 h after administration of the drug. The mice sera resulting after 24 h in the presence of 100 and 300 µg/mouse of Stimforte effectively inhibit the production of HCV. Doses of 150, 200, and 250 µg/mouse are not effective. Stimulation of interferon-β (IFN-β) production is only observed at doses of 100 and 300 µg/mouse, which explains well the neutralizing capacity of the sera. The amount of IFN-γ also correlates well with the antiviral activity and neutralizing activity of mice sera. The drug practically does not stimulate production of IFN-λ. Thus, the neutralizing activity of sera and the antiviral activity are largely determined by the 1st and 2nd IFN groups.

中文翻译：

---

药物Stimforte抑制慢性丙型肝炎感染的机制

摘要

已经研究了药物Stimforte对丙型肝炎病毒（HCV）感染的影响。Stimforte在给药后24小时内以100μg/小鼠的剂量部分抑制HCV感染，几乎完全以300μg/小鼠的剂量完全抑制。在100和300 µg /小鼠的Stimforte存在下24小时后产生的小鼠血清可有效抑制HCV的产生。150、200和250 µg /小鼠的剂量无效。仅在以100和300 µg /小鼠的剂量观察到干扰素-β（IFN-β）的产生，这很好地解释了血清的中和能力。IFN-γ的量也与小鼠血清的抗病毒活性和中和活性密切相关。该药物实际上不刺激IFN-λ的产生。从而，