Abstract

The participation of mesenchymal stromal cells (MSCs) in the regeneration of muscle tissue was analyzed. It is shown that rat bone marrow MSCs do not show potency for myogenic differentiation in vitro under the influence of appropriate inducers and rarely fuse with myoblasts when co-cultured. However, the factors they release stimulate differentiation of myogenic cells. It is noted that in vivo, when combined with minced muscle tissue, MSCs enhance myogenesis and angiogenesis, and when injected into injured muscle, they improve the course of the recovery process, as well as the medium conditioned by them. The paracrine mechanism of the influence of MSCs on skeletal muscle regeneration has been established.

中文翻译：

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间充质基质细胞的成肌潜能及其对骨骼肌再生的影响

摘要

分析了间充质基质细胞（MSCs）在肌肉组织再生中的参与。结果表明，大鼠骨髓间充质干细胞在合适的诱导剂的作用下，在体外没有表现出成肌分化的能力，在共培养时很少与成肌细胞融合。然而，它们释放的因子刺激成肌细胞的分化。值得注意的是，在体内，当与碎碎的肌肉组织结合时，MSC增强了肌肉的生成和血管生成，当注射到受伤的肌肉中时，它们改善了恢复过程的过程，并改善了它们所适应的培养基。已经建立了MSC对骨骼肌再生的影响的旁分泌机制。