Here, an unprecedented synthesis method for nickel oxide nanoparticles (NiO-NPs) was facilitated using Salvia hispanica leaf extracts with the assistance of a high gravity rotating packed bed (RPB) system that enabled fast mass transfer and molecular mixing. The synthesized nanoparticles were anchored on the surface of biodegradable chitosan nanobeads and their photocatalytic activity was evaluated by the degradation of methylene blue. Additionally, the potential biological activities of NiO-NPs in terms of antibacterial (Staphylococcus aureus and Escherichia coli for 24 hours), cytotoxicity (using the PC12 cell line for 24 and 72 hours), and antioxidant activities (based on the discoloration of the methanolic solution of DPPH) were assessed. This novel approach for NiO-NPs@Chitosan synthesis as mediated by a renewable plant extract and facilitated by a high-gravity method, led to the greener synthesis of nanoparticles with significant antibacterial and photocatalytic properties.

中文翻译：

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NiO-NPs的高重力辅助绿色合成固定在可生物降解纳米珠的表面，具有潜在的生物医学应用前景。

在这里，借助丹参叶提取物借助高重力旋转填充床（RPB）系统促进了前所未有的合成氧化镍纳米颗粒（NiO-NPs）的方法，该系统实现了快速的质量转移和分子混合。合成的纳米颗粒被锚定在可生物降解的壳聚糖纳米珠的表面，并通过亚甲基蓝的降解来评估其光催化活性。此外，就抗菌（金黄色葡萄球菌和大肠杆菌）而言，NiO-NP的潜在生物活性持续24小时），细胞毒性（使用PC12细胞系分别持续24和72小时）和抗氧化活性（基于DPPH甲醇溶液的变色）进行了评估。NiO-NPs @壳聚糖合成的这种新颖方法是由可再生植物提取物介导并由高重力法促进的，从而使具有重要抗菌和光催化性能的纳米颗粒的绿色合成得以实现。