The ortho-silicic acid (H₄SiO₄) plays an essential role in delivering silicon to body cells and the monomeric ortho-silicic acid is the most bioavailable source of silicon for humans. This study reveals that the ortho-silicic acid (OSA) modifies the tissue of a healthy and pathological hypotrophic amnion, thermal burn skin and, additionally, the OSA-incubated serum. Changes in the tissue modified by the ortho-silicic acid were traced on the molecular level with the use of FTIR spectroscopy. The most interesting area of tissue modification with the use of OSA acid solutions is the appearance of the 1085 cm^-1 Si-O-Si band which is optimal for the 1:6000 OSA concentration. Microbiological studies aiming at anticipating anti-inflammatory and antibacterial bioactivity revealed that the skin samples and amniotic samples were characterised by good resistance to the following bacteria: Enterococcus faecalis, Staphylococcus aureus and Escherichia coli (medium growth inhibition zone: 0.5-4 mm). The present study determined the concentration and the composition of the solutions to be used in the future to create innovative modifiers (active dressings or new dietary supplements) enhancing tissue regeneration.

中文翻译：

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稳定的原硅酸作为组织初步比较生物材料研究的改性剂。

原硅酸（H 3 SiO 3）在将硅输送到人体细胞中起着至关重要的作用，而单体原硅酸是人类生物利用度最高的硅源。这项研究表明，原硅酸（OSA）可以修饰健康病理性营养不良性羊膜，热灼伤皮肤以及OSA孵育血清的组织。使用FTIR光谱在分子水平上追踪了原硅酸修饰的组织的变化。使用OSA酸性溶液进行组织修饰最有趣的领域是1085 cm ^-1的外观Si-O-Si谱带最适合于1：6000 OSA浓度。针对预期的抗炎和抗菌生物活性的微生物学研究表明，皮肤样品和羊膜样品的特征是对以下细菌具有良好的抵抗力：粪肠球菌，金黄色葡萄球菌和大肠杆菌（中等生长抑制区：0.5-4 mm）。本研究确定了溶液的浓度和组成，这些溶液将在将来用于创建创新的改良剂（活性敷料或新的膳食补充剂）来增强组织再生。