How LINC complexes mediate nuclear mechanotransduction remains unclear. In this issue, Déjardin, Carollo, et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201908036) show that the LINC complex protein nesprin-2G is a mechanosensor of epithelial–mesenchymal transitions (EMTs), recruiting α-catenin to the nucleus to attenuate Wnt/β-catenin signaling.

中文翻译：

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Nesprin-2G 张力微调 Wnt/β-连环蛋白信号传导


LINC 复合物如何介导核力转导仍不清楚。在本期中，Déjardin、Carollo 等人。 (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201908036) 表明 LINC 复合蛋白 nesprin-2G 是上皮-间质转化 (EMT) 的机械传感器，将 α-连环蛋白募集到细胞核减弱 Wnt/β-catenin 信号传导。