Objective

The purpose of this study was to identify cardiac biomarkers of disordered eating as a function of diagnostic subtype as assessed via self-report inventory.

Method

Mean heart rate (HR), systolic and diastolic blood pressure, mean R wave amplitude (mV), mean T wave amplitude (mV), QTc interval (sec), Tpeak-Tend interval prolongation (sec), QTc interval prolongation (sec), QRS prolongation (sec), and spectral indicators of cardiac dysfunction (LF/HF spectral ratio, HF spectral power) were assessed via electrocardiography among women with no eating disorder symptoms (n = 32), subclinical eating disorder symptoms (n = 92), anorexia nervosa (n = 7), bulimia nervosa (n = 89), binge eating disorder (BED: n = 20), and other specified feeding and eating disorders (OSFED: n = 19).

Results

MANOVA results showed statistically significant group differences. Follow-up tests revealed significantly decreased mean R wave amplitude among participants with self-indicated clinical (bulimia nervosa, binge eating disorder) and subclinical forms of disordered eating compared to asymptomatic controls.

Discussion

Results suggest decreased mean R wave amplitude is a promising cardiac biomarker of disordered eating.

中文翻译：

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饮食失调的心脏生物标志物作为诊断亚型的函数。

 客观的

本研究的目的是通过自我报告清单评估，确定饮食失调的心脏生物标志物作为诊断亚型的函数。

 方法

平均心率 (HR)、收缩压和舒张压、平均 R 波幅度 (mV)、平均 T 波幅度 (mV)、QTc 间期（秒）、Tpeak-Tend 间期延长（秒）、QTc 间期延长（秒）通过心电图对无饮食失调症状的女性 ( n = 32) 和亚临床饮食失调症状 ( n = 92) 的女性进行心电图评估，QRS 延长（秒）和心功能障碍的频谱指标（LF/HF 频谱比、HF 频谱功率） 、神经性厌食症 ( n = 7)、神经性贪食症 ( n = 89)、暴食症 (BED: n = 20) 以及其他特定的喂养和进食障碍 (OSFED: n = 19)。

 结果

多元方差分析结果显示组间差异具有统计学意义。后续测试显示，与无症状对照组相比，自我表明临床（神经性贪食症、暴食症）和亚临床形式饮食失调的参与者的平均 R 波振幅显着降低。

 讨论

结果表明，平均 R 波振幅降低是饮食失调的一个有前途的心脏生物标志物。