The ubiquitin (Ub)-proteasome system (UPS) targets various cellular proteins for degradation. It has been found that defects in the UPS play a crucial role in the pathogenesis of Alzheimer's disease (AD), as the existence of Ub immunoreactivity in AD-linked neuronal inclusions, including neurofibrillary tangles, is observed in all types of AD cases. Current investigations have shown that components of the UPS can be connected with the early stage of AD, which is characterized by synaptic dysfunction, and to the late phases of the disease, marked by neurodegeneration. Although the significance of UPS in the pathogenesis of AD has been emphasized, targeted treatment at the main components of these pathways has a great perspective in advancing new therapeutic interventions for AD. In this review, we emphasize the relationship between UPS and AD pathology. We also represent the recent therapeutic advancements targeting UPS components in AD.

泛素（Ub）-蛋白酶体系统（UPS）靶向各种细胞蛋白进行降解。已经发现，UPS中的缺陷在阿尔茨海默氏病（AD）的发病机理中起着至关重要的作用，因为在所有类型的AD病例中都观察到了AD连接的神经元包涵体（包括神经原纤维缠结）中Ub免疫反应性的存在。当前的研究表明，UPS的组件可以与以突触功能障碍为特征的AD早期阶段以及以神经变性为特征的疾病晚期阶段相关。尽管已经强调了UPS在AD发病机理中的重要性，但针对这些途径的主要组成部分的靶向治疗在推进AD的新治疗干预方面具有广阔的前景。在这篇评论中 我们强调UPS与AD病理之间的关系。我们还代表了针对AD中UPS组件的最新治疗进展。