In this review, nanoscale-based drug delivery systems, particularly in relevance to the antiglaucoma drugs, have been discussed. In addition to that, the latest computational/in silico advances in this field are examined in brief. Using nanoscale materials for drug delivery is an ideal option to target tumours, and the drug can be released in areas of the body where traditional drugs may fail to act. Nanoparticles, polymeric nanomaterials, single-wall carbon nanotubes (SWCNTs), quantum dots (QDs), liposomes and graphene are the most important nanomaterials used for drug delivery. Ocular drug delivery is one of the most common and difficult tasks faced by pharmaceutical scientists because of many challenges like circumventing the blood-retinal barrier, corneal epithelium and the blood-aqueous barrier. Authors found compelling empirical evidence of scientists relying on in-silico approaches to develop novel drugs and drug delivery systems for treating glaucoma. This review in nanoscale drug delivery systems will help us understand the existing queries and evidence gaps and will pave the way for the effective design of novel ocular drug delivery systems.

在这篇综述中，已经讨论了基于纳米级的药物递送系统，特别是与抗青光眼药物有关的系统。除此之外，还将简要介绍该领域的最新计算/计算机技术进展。使用纳米级材料进行药物输送是靶向肿瘤的理想选择，并且药物可以在传统药物可能无法起作用的体内区域释放。纳米颗粒，聚合物纳米材料，单壁碳纳米管（SWCNT），量子点（QD），脂质体和石墨烯是用于药物输送的最重要的纳米材料。由于绕过血视网膜屏障，角膜上皮和血水屏障等许多挑战，眼部药物递送是药物科学家面临的最常见和最困难的任务之一。作者发现了令人信服的经验证据，证明了科学家们依靠计算机内方法来开发用于治疗青光眼的新型药物和药物递送系统。纳米级药物输送系统的这篇综述将帮助我们了解现有的查询和证据方面的差距，并将为有效设计新型眼用药物输送系统铺平道路。