Vertebrates sense a large variety of sensory stimuli that ranges from temperature, volatile and nonvolatile chemicals, touch, pain, light, sound and gravity. To achieve this, they use specialized cells present in sensory organs and cranial ganglia. Much of our understanding of the transcription factors and mechanisms responsible for sensory cell specification comes from cell-lineage tracing and genetic experiments in different species, but recent advances in single-cell transcriptomics, high-resolution imaging and systems biology approaches have allowed to study these processes in an unprecedented resolution. Here I will point to the transcription factor programs driving cell diversity in the different sensory organs of vertebrates to then discuss in vivo data of how cell specification is coupled with tissue morphogenesis.

中文翻译：

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脊椎动物颅内感觉系统中细胞分化和分化的机制。

脊椎动物会感觉到各种各样的感觉刺激，包括温度，挥发性和非挥发性化学物质，触摸，疼痛，光线，声音和重力。为此，他们使用感觉器官和颅神经节中存在的专门细胞。我们对负责感觉细胞规范的转录因子和机制的大多数理解来自不同物种的细胞谱系追踪和遗传实验，但是单细胞转录组学，高分辨率成像和系统生物学方法的最新进展已允许研究这些以前所未有的分辨率进行处理。在这里，我将指出在脊椎动物的不同感觉器官中驱动细胞多样性的转录因子程序，然后讨论细胞规格与组织形态发生如何结合的体内数据。