Background: Given the minimal capacity and sometimes the failure of the mammalian nervous system to regenerate and repair itself after damage, strategies are required to help enhance this regenerative process. Adipose-derived Mesenchymal Stem Cells (ADMSCs) are likely candidates to assist in the recovery process due to their ability to differentiate into neural cells. Successful implementation of this intervention in a clinical setting would increase the rate of recovery following traumatic brain injury.

Review: Various strategies have been attempted to differentiate ADMSCs into neural cells for clinical use. Such methods have not been entirely successful in the development of functioning specialized cells for subsequent practical use. Therefore, the implementations of this differentiation technique in the clinical trial have not been effective. In this article, the potential of differentiating ADMSCs into neural cells and the various methods employed, including biological induction, chemical induction and photobiomodulation (PBM) will be discussed, where the combined use of transducers and PBM for neural differentiation of ADMSCs is also deliberated.

Conclusion: PBM shows promise as an avenue for effective ADMSCs differentiation into neural cells and their proliferation. Applying PBM with optimized biological factors and chemical inducers may prove to be an effective tool for clinical application.

背景：鉴于哺乳动物神经系统在受损后再生和修复自身的能力极低，有时甚至失败，需要采取策略来帮助增强这种再生过程。脂肪来源的间充质干细胞 (ADMSCs) 可能是辅助恢复过程的候选者，因为它们能够分化为神经细胞。在临床环境中成功实施这种干预将提高创伤性脑损伤后的恢复率。

综述：已尝试多种策略将 ADMSCs 分化为神经细胞以供临床使用。这些方法在开发功能性特化细胞以供随后的实际使用方面并不完全成功。因此，这种分化技术在临床试验中的实施效果不佳。在本文中，将讨论将 ADMSCs 分化为神经细胞的潜力以及所采用的各种方法，包括生物诱导、化学诱导和光生物调节 (PBM)，其中还讨论了换能器和 PBM 在 ADMSCs 神经分化中的联合使用。

结论：PBM 有望成为有效的 ADMSCs 分化为神经细胞及其增殖的途径。应用具有优化生物因子和化学诱导剂的 PBM 可能被证明是临床应用的有效工具。