Background: Alzheimer’s disease is an irreversible, progressive brain disorder manifested with symptoms like loss of memory (known as dementia), personality changes, loss of cognition, impaired movement, confusion, deteriorated planning and thought process. Neurodegeneration in Alzheimer’s disease is the result of the deposition of protein beta-amyloid that forms plaques and another protein called tau, forming tangles that prevent the proper functioning of nerve cells in the brain.

Methods: The goal of the review was to comprehensively study the utilization of nanotechnology and the role that carbon nanotubes can play as a drug delivery system for the amelioration of Alzheimer’s disease.

Results: Nanotechnology is one of the most researched domains of modern science. It contributes significantly to therapeutics by facilitating drug therapy to reach the target sites, which are otherwise difficult to reach with conventional drug delivery systems. Carbon nanotubes are the allotropes of carbon in which several carbon atoms bind with each other to form a cylindrical or a tube-like structure. The carbon nanotubes possess several unique qualities, which confer them with a high potential of being utilized as an efficient drug delivery system. They offer high drug loading and can readily cross the toughest biological barriers like the BBB. Carbon nanotubes also facilitate the passage of drugs to the brain via the olfactory route, which further helps in restoring normal autophagy, thus preventing the elimination of autophagic chemicals. They can carry a vast range of cargos, including drugs, antigens, genetic materials, and biological macromolecules.

Conclusion: Carbon nanotubes are a highly promising drug delivery system for anti-Alzheimer’s drugs. They have the potential of overcoming the various biological barriers like the BBB. However, more extensive research is required so as to set up a firm base for the development of advanced commercial products based on carbon nanotubes for the treatment of Alzheimer’s disease.

背景：阿尔茨海默病是一种不可逆转的进行性脑部疾病，表现为记忆力减退（称为痴呆症）、人格改变、认知丧失、运动受损、意识模糊、计划和思维过程恶化等症状。阿尔茨海默病中的神经变性是形成斑块的蛋白质 β-淀粉样蛋白和另一种称为 tau 的蛋白质沉积的结果，从而形成阻止大脑中神经细胞正常运作的缠结。

方法：该评价的目的是全面研究纳米技术的利用以及碳纳米管作为药物递送系统在改善阿尔茨海默病方面的作用。

结果：纳米技术是现代科学中研究最多的领域之一。它通过促进药物治疗到达目标位点而对治疗做出重大贡献，否则传统药物递送系统很难到达这些位点。碳纳米管是碳的同素异形体，其中几个碳原子相互结合形成圆柱形或管状结构。碳纳米管具有多种独特的品质，这赋予它们作为高效药物输送系统的巨大潜力。它们提供高载药量，并且可以轻松穿过最艰难的生物屏障，如 BBB。碳纳米管还促进药物通过嗅觉途径进入大脑，这进一步有助于恢复正常的自噬，从而阻止自噬化学物质的消除。

结论：碳纳米管是一种极具前景的抗阿尔茨海默病药物递送系统。它们有可能克服 BBB 等各种生物障碍。然而，还需要更广泛的研究，以便为开发基于碳纳米管的用于治疗阿尔茨海默病的先进商业产品奠定坚实的基础。