Background: Resveratrol, a natural polyphenol product, is used in plant defense from fungal and microbial aggression. It is found naturally, especially in plants such as grapes, peanuts, and berries. It has the highest concentrations in blueberries, mulberries, blackberries, and the skin of red grapes. Resveratrol has various pharmacological properties such as anti-inflammatory, cytoprotective, and antineoplastic activities.

Methods: We conducted a literature survey using standard tools such as Google, Reaxys, Scifinder, Scihub, and patent Espacenet to compile the biosynthetic pathways, all organic synthetic methods, and biological activities reported for resveratrol till date.

Results: More than one hundred research articles and patents were referred to write this review. About twenty-five of them are related to chemical synthesis, and the rests are about the source, pharmacological activity, and other properties of resveratrol. This study reveals that many common pathways are involved in various pharmacological activities, which can be useful for treating various diseases based on the pathways involved. Reactions such as Pfitzner-Moffatt oxidation, Wittig-Horner condensation, Mizoroki–Heck, Perkin, Wittig, etc. have been used in resveratrol synthesis. A structure-activity relationship was also established based on its analogs and derivatives.

Conclusion: This review examined and reported all the published biological activities and chemical syntheses of resveratrol apart from the biosynthetic pathway. Due to its valuable biological activities, various synthetic approaches have been reported till date. The reported synthetic operations are suitable for large-scale industrial production. Moreover, these comprehensive synthetic procedures could be utilized in the preparation of stilbenes and other related compounds in future endeavors.

背景：白藜芦醇是一种天然多酚产品，用于植物防御真菌和微生物侵袭。它是天然存在的，尤其是在葡萄、花生和浆果等植物中。它在蓝莓、桑葚、黑莓和红葡萄皮中的含量最高。白藜芦醇具有多种药理特性，例如抗炎、细胞保护和抗肿瘤活性。

方法：我们使用谷歌、Reaxys、Scifinder、Scihub 和专利 Espacenet 等标准工具进行了文献调查，以汇编迄今为止报道的白藜芦醇的生物合成途径、所有有机合成方法和生物活性。

结果： 一百多篇研究论文和专利被引用来撰写这篇评论。其中约二十五个与化学合成有关，其余的则与白藜芦醇的来源、药理活性和其他性质有关。该研究表明，许多常见的通路都涉及各种药理活性，可根据所涉及的通路用于治疗各种疾病。Pfitzner-Moffatt 氧化、Wittig-Horner 缩合、Mizoroki-Heck、Perkin、Wittig 等反应已用于白藜芦醇的合成。还基于其类似物和衍生物建立了构效关系。

结论：本综述检查并报告了除生物合成途径外所有已发表的白藜芦醇生物活性和化学合成。由于其有价值的生物活性，迄今为止已经报道了各种合成方法。报道的合成操作适用于大规模工业生产。此外，这些综合的合成程序可用于在未来的努力中制备二苯乙烯和其他相关化合物。