Centriole duplication occurs once per cell cycle. Since only a single daughter centriole is assembled adjacent to each mother centriole, symmetry around the mother centriole must be broken in the process of centriole duplication. Recent studies have established that Plk4, a master kinase for centriole duplication, can self-assemble into condensates, and have suggested that this Plk4 self-assembly is the key to symmetry breaking. Here, we present the current hypotheses for how Plk4 could break symmetry around the mother centriole via autonomous regulation. After this initial symmetry-breaking process, the ring-to-dot conversion of Plk4 around the mother centriole completes the selection of the site for procentriole formation. We also discuss how this dynamic transition contributes to the strict regulation of centriole duplication.

中文翻译：

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对中心粒复制对称性破坏的新见解：中心粒复制理论的最新观点。

每个细胞周期发生一次中心粒复制。由于只有一个子中心粒与每个母中心粒相邻组装，因此在中心粒复制过程中必须打破围绕母中心粒的对称性。最近的研究已经确定，中心粒复制的主激酶 Plk4 可以自组装成凝聚物，并表明这种 Plk4 自组装是对称性破坏的关键。在这里，我们提出了 Plk4 如何通过自主调节打破围绕母中心粒的对称性的当前假设。在这个初始的对称破坏过程之后，围绕母中心粒的 Plk4 环到点的转换完成了原中心粒形成位点的选择。我们还讨论了这种动态转变如何有助于严格调节中心粒复制。