An accurate centriolar structure is crucial for organelle function, necessitating the existence of molecular mechanisms for the tight control of centriole assembly. Formation of an initial scaffold, the cartwheel, assists the correct placement of centriolar proteins during assembly and templates key structural parameters of the organelle. Past work illustrated how cartwheel and centriolar symmetry are linked, and grounded organelle symmetry and diameter to the properties of the centriolar protein SAS-6. However, questions remained over how centriole polarity and length are controlled. Recent advances in resolving cartwheel structure and cell biology showed that these assemblies are polarized and that their length is under the control of a homeostatic mechanism. These cartwheel properties may, in turn, influence the centriolar polarity and length.

中文翻译：

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中心侧车轮结构：对称、堆叠和极化。

准确的中心粒结构对于细胞器功能至关重要，需要存在严格控制中心粒组装的分子机制。初始支架的形成，侧手翻，有助于在组装和模板细胞器的关键结构参数期间正确放置中心蛋白。过去的工作说明了侧手翻和中心粒对称性是如何关联的，以及细胞器对称性和直径与中心粒蛋白 SAS-6 的特性之间的联系。然而，关于如何控制中心粒极性和长度的问题仍然存在。解析车轮结构和细胞生物学的最新进展表明，这些组件是极化的，它们的长度受稳态机制的控制。这些车轮特性可能反过来影响中心极性和长度。