PURPOSE To determine the association of pre-diagnostic allostatic load (AL) with health-related quality of life (HRQOL) among Black women with breast cancer. METHODS In a sample of 409 Black women with non-metastatic breast cancer enrolled in the Women's Circle of Health Follow-Up Study (WCHFS), two pre-diagnostic AL measures were estimated using medical records data from up to 12 months prior to breast cancer diagnosis: AL-lipid/metabolic profile-based measure and AL-inflammatory profile-based measure. HRQOL was assessed approximately 24 months post diagnosis, using the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) instrument, including 5 subscale scores [presented by physical well-being (PWB), social & family well-being (SFWB), emotional well-being (EWB), functional well-being (FWB), and breast cancer-specific scale (BCS)] and 3 derived total scores [presented by trial outcome index (TOI), Functional Assessment of Cancer Therapy-General (FACT-G) and FACT-B]. We used multivariable logistic regression models, using dichotomized AL scores (lower AL: 0-3 points, higher AL: 4-8 points), to assess the associations between the two pre-diagnostic AL measures and HRQOL. RESULTS Higher pre-diagnostic AL was associated with poorer FWB and lower FACT-G, but these associations were statistically significant for the AL-inflammatory profile-based measure (FWB: OR 1.63, 95% CI 1.04, 2.56; FACT-G: OR 1.62, 95% CI 1.04, 2.54), but not the AL-lipid/metabolic profile-based measure (FWB: OR 1.45, 95% CI 0.81, 2.59; FACT-G: OR 1.33, 95% CI 0.75, 2.37). CONCLUSION These findings suggest that higher AL, particularly when measured using the inflammatory profile-based measure, was associated with poorer HRQOL, namely FWB and FACT-G, among Black breast cancer survivors.

中文翻译：

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一组黑人乳腺癌幸存者的诊断前分配负荷和健康相关的生活质量。

目的 确定黑人女性乳腺癌诊断前分配负荷 (AL) 与健康相关生活质量 (HRQOL) 的关联。方法 在参加妇女健康随访研究 (WCHFS) 的 409 名患有非转移性乳腺癌的黑人女性样本中，使用乳腺癌发生前长达 12 个月的医疗记录数据估计了两项诊断前 AL 测量值诊断：基于AL-脂质/代谢特征的测量和基于AL-炎症特征的测量。在诊断后大约 24 个月，使用癌症治疗功能评估 - 乳腺癌 (FACT-B) 工具评估 HRQOL，包括 5 个分量表评分 [由身体健康 (PWB)、社会和家庭幸福 (SFWB) 呈现) , 情绪幸福 (EWB), 功能幸福 (FWB), 和乳腺癌特定量表 (BCS)] 和 3 个衍生总分 [由试验结果指数 (TOI)、癌症治疗的功能评估-一般 (FACT-G) 和 FACT-B 呈现]。我们使用多变量逻辑回归模型，使用二分 AL 评分（较低 AL：0-3 分，较高 AL：4-8 分）来评估两种预诊断 AL 测量值与 HRQOL 之间的关联。结果 较高的诊断前 AL 与较差的 FWB 和较低的 FACT-G 相关，但这些关联对于基于 AL 炎症特征的测量具有统计学意义（FWB：OR 1.63，95% CI 1.04, 2.56；FACT-G：OR 1.62, 95% CI 1.04, 2.54)，但不是基于 AL 脂质/代谢特征的测量（FWB：OR 1.45，95% CI 0.81，2.59；FACT-G：OR 1.33，95% CI 0.75，2.37）。结论 这些发现表明较高的 AL，