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Multiple genotypes of enterovirus G carrying a papain-like cysteine protease (PL-CP) sequence circulating on two pig farms in Japan: first identification of enterovirus G10 carrying a PL-CP sequence.
Archives of Virology ( IF 2.5 ) Pub Date : 2020-09-19 , DOI: 10.1007/s00705-020-04816-y
Yuya Sekiguchi 1 , Ayaka Nagata 1 , Fujiko Sunaga 1 , Toru Oi 2 , Ryo Imai 3 , Hiroo Madarame 1 , Yukie Katayama 3 , Mami Oba 3 , Tamaki Okabayashi 4 , Naoaki Misawa 4 , Tomoichiro Oka 5 , Tetsuya Mizutani 3 , Makoto Nagai 1, 3
Affiliation  

Two and three genotypes of enterovirus G (EV-G) carrying a papain-like cysteine protease (PL-CP) sequence were detected on two pig farms and classified into genotypes G1 and G10, and G1, G8, and G17, respectively, based on VP1 sequences. A G10 EV-G virus bearing a PL-CP sequence was detected for the first time. Phylogenetic analysis of the P2 and P3 regions grouped the viruses by farm with high sequence similarity. Furthermore, clear recombination break points were detected in the 2A region, suggesting that PL-CP EV-G-containing strains gained sequence diversity through recombination events among the multiple circulating EV-G genotypes on the farms.



中文翻译:

在日本两个养猪场中流通的带有木瓜蛋白酶样半胱氨酸蛋白酶(PL-CP)序列的肠道病毒G的多种基因型:首次鉴定带有PL-CP序列的肠道病毒G10。

在两个猪场中检测到带有木瓜蛋白酶样半胱氨酸蛋白酶(PL-CP)序列的肠道病毒G(EV-G)的两种和三种基因型,分别基于基因型G1和G10,G1,G8和G17在VP1序列上。首次检测到带有PL-CP序列的G10 EV-G病毒。对P2和P3区域的系统发育分析按具有高度序列相似性的场对病毒进行了分组。此外,在2A区域检测到清晰的重组断裂点,这表明包含PL-CP EV-G的菌株通过农场中多个循环EV-G基因型之间的重组事件获得了序列多样性。

更新日期:2020-10-30
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