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An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents.
Current Topics in Medicinal Chemistry ( IF 2.9 ) Pub Date : 2020-01-01 , DOI: 10.2174/1568026620999200917154225
Yanna Mao 1 , Kunjal Soni 2 , Chetan Sangani 2 , Yongfang Yao 1, 3
Affiliation  

Cancer is one of the most difficult diseases and causes of death for many decades. Many pieces of research are continuously going on to get a solution for cancer. Quinoline and isoquinoline derivatives have shown their possibilities to work as an antitumor agent in anticancer treatment. The members of this privileged scaffold quinoline and isoquinoline have shown their controlling impacts on cancer treatment through various modes. In particular, this review suggests the current scenario of quinoline and isoquinoline derivatives as antitumor agents and refine the path of these derivatives to find and develop new drugs against an evil known as cancer.

中文翻译:

特权支架概述:药物化学中作为抗癌剂的喹啉和异喹啉。

几十年来,癌症是最难治的疾病和死亡原因之一。许多研究都在不断进行,以获得癌症的解决方案。喹啉和异喹啉衍生物已显示出它们在抗癌治疗中作为抗肿瘤剂发挥作用的可能性。这种特权支架喹啉和异喹啉的成员已经通过各种模式显示了它们对癌症治疗的控制影响。特别是,这篇综述提出了喹啉和异喹啉衍生物作为抗肿瘤药物的现状,并改进了这些衍生物的途径,以寻找和开发对抗癌症的新药。
更新日期:2020-09-17
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