Background: Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition.

Objectives: The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty Virus-Like Particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications.

Methods: The encapsidation of magnetic materials and anticancer drugs was achieved. ^SuperscriptCPMV denotes molecules attached to the external surface of CPMV and CPMV_Subscript denotes molecules within the interior of the capsid.

Results: Here, the generation of novel VLPs incorporating iron-platinum nanoparticles _TCPMV_FePt and cisplatin (Cis) (_TCPMV_Cis) is reported. _TCPMV_Cis exhibited a cytotoxic IC₅₀ of _TCPMV_Cis on both A549 and MDA-MB-231 cell lines of 1.8 μM and 3.9 μM, respectively after 72 hours of incubation. The _TCPMV_FePt were prepared as potential MRI contrast agents.

Conclusion: Cisplatin loaded VLP (_TCPMV_Cis) is shown to enhance cisplatin cytotoxicity in cancer cell lines with its potency increased by 2.3-folds.

背景：在过去的几十年中，病毒纳米粒子在治疗诊断学应用中得到了广泛的研究。病毒是特征明确的、天然存在的纳米粒子，可以大量生产，在结构和组成上都具有高度的相似性。

目的：植物病毒豇豆花叶病毒（CPMV）已被创新地用作纳米支架。利用空病毒样颗粒 (VLP) 的内腔将治疗药物包含在衣壳中，为药物递送和成像应用开辟了许多机会。

方法：实现了磁性材料和抗癌药物的衣壳化。^上标CPMV 表示连接到 CPMV 外表面的分子，CPMV 下_标表示衣壳内部的分子。

结果：在此，报道了包含铁铂纳米粒子_T CPMV _FePt和顺铂 (Cis) ( _T CPMV _Cis )的新型 VLP 的产生。_Ť CPMV_顺表现出细胞毒性的IC ₅₀的_Ť CPMV_顺在两个A549和1.8μM和3.9μM，孵育72小时后，分别的MDA-MB-231细胞系。该_牛逼CPMV_的FePt制备作为潜在的MRI造影剂。

结论： 载有顺铂的 VLP ( _T CPMV _Cis ) 显示可增强癌细胞系中顺铂的细胞毒性，其效力增加了 2.3 倍。