Nuclear Factor κB (NF-κB) is a family of five related transcription factors that recognize a κB DNA element on the promoter and enhancer regions of target genes and modulate their expression. Here we report a complete set of ¹H, ¹³C, ¹⁵N backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-κB transcription factor. The chemical shift data constitute a first step towards understanding the mechanism of interaction of the p50 homodimer with DNA.

中文翻译：

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NF-κB转录因子p50亚基的主链和侧链化学位移分配

核因子 κB (NF-κB) 是一个由五个相关转录因子组成的家族，可识别靶基因启动子和增强子区域上的 κB DNA 元件并调节其表达。在这里，我们报告了 NF-κB 转录因子 p50 同二聚体形式的 p50 DNA 结合和二聚化结构域的完整¹ H、 ¹³ C、 ¹⁵ N 主链和侧链共振分配。化学位移数据是了解 p50 同二聚体与 DNA 相互作用机制的第一步。