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Backbone and side-chain chemical shift assignments of p50 subunit of NF-κB transcription factor
Biomolecular NMR Assignments ( IF 0.8 ) Pub Date : 2020-09-16 , DOI: 10.1007/s12104-020-09978-z
Amrinder Singh 1 , H Jane Dyson 1
Affiliation  

Nuclear Factor κB (NF-κB) is a family of five related transcription factors that recognize a κB DNA element on the promoter and enhancer regions of target genes and modulate their expression. Here we report a complete set of 1H, 13C, 15N backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-κB transcription factor. The chemical shift data constitute a first step towards understanding the mechanism of interaction of the p50 homodimer with DNA.



中文翻译:


NF-κB转录因子p50亚基的主链和侧链化学位移分配



核因子 κB (NF-κB) 是一个由五个相关转录因子组成的家族,可识别靶基因启动子和增强子区域上的 κB DNA 元件并调节其表达。在这里,我们报告了 NF-κB 转录因子 p50 同二聚体形式的 p50 DNA 结合和二聚化结构域的完整1 H、 13 C、 15 N 主链和侧链共振分配。化学位移数据是了解 p50 同二聚体与 DNA 相互作用机制的第一步。

更新日期:2020-09-16
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