PURPOSE This study aimed to compare long-term survival outcomes of repeat lumpectomy with total mastectomy after ipsilateral breast tumor recurrence (IBTR) using propensity score matching (PSM). METHODS We retrospectively analyzed patients with IBTR who had undergone initial breast-conserving surgery for breast cancer at our institution between January 1990 and December 2013. The Kaplan-Meier method and Cox proportional hazards model were used to compare survival rates between the two groups. PSM was performed using the following covariates: age at initial operation, initial T stage, N stage, hormone receptor status, human epidermal growth factor receptor 2 status, chemotherapy, radiotherapy, and IBTR tumor size. RESULTS We enrolled 335 IBTR patients with a median follow-up of 126.6 months. No significant differences were observed in the 5-year overall survival (OS), breast cancer-specific survival (BCSS), OS after IBTR, and BCSS after IBTR and 10-year survival probability between the two groups in a multivariate analysis. After PSM, patients who had undergone repeat lumpectomy and total mastectomy (n = 90 in both groups) were included. No significant differences were observed in the 10-year OS (hazard ratio [HR] 1.08, 95% confidence interval [CI] 0.49-2.39), BCSS (HR 0.83, 95% CI 0.35-1.95), OS after IBTR (HR 0.83, 95% CI 0.38-1.83), and BCSS after IBTR (HR 0.64, 95% CI 0.28-1.47) between the two groups. CONCLUSIONS No significant differences were observed in survival outcomes between patients with IBTR who underwent repeat lumpectomy or total mastectomy. Our results can be helpful in selecting the appropriate surgical method for IBTR.

中文翻译：

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重复乳房肿瘤切除术治疗同侧乳腺肿瘤复发的长期生存结果：倾向评分匹配分析。

目的 本研究旨在使用倾向评分匹配 (PSM) 比较同侧乳腺肿瘤复发 (IBTR) 后重复乳房肿瘤切除术与全乳房切除术的长期生存结果。方法 我们回顾性分析了 1990 年 1 月至 2013 年 12 月在我院接受乳腺癌初始保乳手术的 IBTR 患者。采用 Kaplan-Meier 方法和 Cox 比例风险模型比较两组的生存率。PSM 使用以下协变量进行：初始手术年龄、初始 T 分期、N 分期、激素受体状态、人表皮生长因子受体 2 状态、化疗、放疗和 IBTR 肿瘤大小。结果 我们招募了 335 名 IBTR 患者，中位随访时间为 126.6 个月。在多变量分析中，两组之间的 5 年总生存率 (OS)、乳腺癌特异性生存率 (BCSS)、IBTR 后的 OS 和 IBTR 后的 BCSS 以及 10 年生存率没有显着差异。PSM 后，包括接受过重复乳房肿瘤切除术和全乳房切除术的患者（两组中 n = 90）。在 10 年 OS（风险比 [HR] 1.08，95% 置信区间 [CI] 0.49-2.39）、BCSS（HR 0.83，95% CI 0.35-1.95）、IBTR 后 OS（HR 0.83 , 95% CI 0.38-1.83) 和 IBTR 后 BCSS (HR 0.64, 95% CI 0.28-1.47) 在两组之间。结论 接受重复乳房肿瘤切除术或全乳切除术的 IBTR 患者的生存结果没有显着差异。